To gain experience with a fine-wire intramuscular measurement technique for recording of short-latency muscle responses in neck muscles.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Amplitude and timing of short-latency muscle response in a time window of
50-150 ms after stimulus presentation.
Secondary outcome
Reaction times of manual responses to stimuli presented ipsi- and contralateral
of responding hand.
Background summary
The investigation is motivated by the hypothesis that freezing of gait in
Parkinson*s disease (PD) may be explained by bilaterally simultaneous orienting
responses accompanied by short-latency reflex-like activity in axial muscles.
The bilaterally simultaneous nature of these responses interferes with the
normally alternating activation pattern of these muscles during walking, thus
inducing a freezing episode. In order to evaluate this hypothesis in PD, we
first have to gain experience with a fine-wire intramuscular measurement
technique for recording the short-latency muscle responses in neck muscles,
which express the orienting response.
Study objective
To gain experience with a fine-wire intramuscular measurement technique for
recording of short-latency muscle responses in neck muscles.
Study design
Observational study
Study burden and risks
The investigation requires a time investment of 2 hours. Preparation includes
an ultrasound investigation of the neck to identify and localise the relevant
muscles. Subsequently, a needle is inserted in four muscles in order to place
the electrodes. This will cause pain of a level comparable to an intramuscular
injection or venapuncture. Finally, muscle activity will be recorded during a
computerised attention task. The invasive EMG measurements are frequently
carried out in basic and medical research and are not associated with any
risks.
R. Postlaan 4
Nijmegen 6525 GC
NL
R. Postlaan 4
Nijmegen 6525 GC
NL
Listed location countries
Age
Inclusion criteria
Age 20-60 years. Right handed.
Exclusion criteria
- visual impairments
- previous neck trauma or known anatomical neck deformities
- skin disease or infection affecting the suboccipital region
- clotting disorder
- pregnancy
- use of antiplatelet or antithrombotic drugs
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL43616.091.13 |