MIPS Follow up - Local continuation of an observational, double-blind, follow up study as an extension of a randomised double-blind controlled study with a parallel group design on the effect of formula feeding (IF?FOF) supplemented with a mixture of immunologically active neutral and acidic oligosaccharides in healthy term born infants during their first year of life (during MIPS1) on the incidence of atopic diseases and infections around their 3rd year of life until the completion of their 7th

In MIPS1 in a randomised double blind placebo controlled multicenter study to
assess the effect of oligosaccharides added to infant formula feeding the
incidence of atopic diseases was reduced in the first year of life in healthy
term born infamts. There was no reduction in the incidence of fever episodes.
Mips 2 (3-5 years of age) no effect was shown (preliminary results)

Has the supplementation of oligosaccharides in the first year of life an effect
on the incidence of atopic diseases and infections from the 5th until the 7th
year of life in healthy children

Observational follow up study of the Groningen cohort

for the participating children the burden is minimal
-physical examination at home visit
-venapuncture (at home visit) in case of separate informed consent

the parents keep a diary and will be called once per half year
a feaces sample is collected at the home visit day