Research with human participants

Overview of medical research in the Netherlands

The effect of HPP-A in the transplant model of psoriasis; in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intra-dermally into the transplant

Published:
Last updated:

Client wishes to see if HPP-A is active in the transplant model of psoriasis

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Ethical review
Approved WMO
Status
Recruitment stopped
Health condition type
Other condition
Study type
Observational invasive

ID

NL-OMON38813

Source

ToetsingOnline

Brief title

The effect of HPP-A in the transplant model of psoriasis;

Condition

  • Other condition
  • Autoimmune disorders
  • Epidermal and dermal conditions

Synonym

psoriasis

Health condition

een onderzoek naar werking van een middel in een model

Research involving

Human

Sponsors and support

Primary sponsor :
High Point Pharmaceuticals
Source(s) of monetary or material Support :
Industry

Intervention

Keyword :
psoriasis, skin, therapies, transplant

Outcome measures

Primary outcome

NVT

Secondary outcome

NVT

Background summary

Client wishes to develop a drug against psoriasis

Study objective

Client wishes to see if HPP-A is active in the transplant model of psoriasis

Study design

Volunteers donate 3 x 5mm diameter skin biopsies and 27 ml blood.

Study burden and risks

NVT

Public
High Point Pharmaceuticals

Mendenhall Oaks Pkwy 4170
High Point, NC 27165
US
Scientific
High Point Pharmaceuticals

Mendenhall Oaks Pkwy 4170
High Point, NC 27165
US

Listed location countries

Netherlands

Age

Adults (18-64 years)
Elderly (65 years and older)

Inclusion criteria

Patients with light to mild psoriasis vulgaris

Exclusion criteria

Volunteers cannot be treated systemically (for psoriasis)
Volunteers cannot have UV/light therapy
Volunteers cannot be taking immune-modulating drugs for other diseases
Volunteers should not have problems with the Köbner phenomenon.

Design

Study type :
Observational invasive
Masking :
Open (masking not used)
Control :
Uncontrolled
Primary purpose :
Other

Recruitment

NL
Recruitment status
:
Recruitment stopped
Start date (anticipated) :
Enrollment :
14
Type :
Anticipated

Approved WMO
Date :
Application type :
First submission
Review commission :
METC Leiden-Den Haag-Delft (Leiden)

metc-ldd@lumc.nl

Followed up by the following (possibly more current) registration

No registrations found.

Other (possibly less up-to-date) registrations in this register

No registrations found.

In other registers

Register ID
CCMO NL42859.098.12