To explore the effect of stress on the neural correlates of emotion regulation, we will combine sophisticated behavioural tasks in a functional magnetic resonance imaging (fMRI) setting with a well-established stress-induction procedure.
ID
Source
Brief title
Condition
- Other condition
- Anxiety disorders and symptoms
Synonym
Health condition
gezonde deelnemers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
* Functional MRI
* Behavioural measures of attentional bias (reaction time, accuracy)
* Psychophysiological measures of fear (skin conductance, startle response)
Secondary outcome
* Salivary hormone concentrations
* Heart rate
* Self-report questionnaires
Background summary
Cognitive emotion regulation emerges from an interaction between prefrontal
cognitive and limbic emotional processing regions. Stress is found to have a
profound impact on both emotional processing and cognitive functioning.
However, how stress affects cognitive emotion regulation is currently unclear.
Study objective
To explore the effect of stress on the neural correlates of emotion regulation,
we will combine sophisticated behavioural tasks in a functional magnetic
resonance imaging (fMRI) setting with a well-established stress-induction
procedure.
Study design
A between-subject design will be used where stress level will be manipulated
between subjects while assessing emotion regulation with our experiments. Tests
will take place in the afternoon on two consecutive days for both groups. The
second day consists for a memory test to assess how stress effects on emotion
regulation impact on the encoding of emotional information into memory
Study burden and risks
The established stress induction and anxiety provocation procedures will most
likely cause a moderate level of acute subjective distress in these healthy
participants. This is inherent to the study topic. However, based on extensive
previous experience with these procedures (see for example CMO protocol number
2010/257 and CMO protocol 2011/382) the risk associated with participation can
be considered negligible and the burden can be considered minimal. Neither
pharmacological nor (otherwise) invasive interventions are applied.
Kapittelweg 29
Nijmegen 6525EN
NL
Kapittelweg 29
Nijmegen 6525EN
NL
Listed location countries
Age
Inclusion criteria
* Because previous work showed that menstrual cycle influences neural functioning and the stress response in free-cycling women, only men and women taking anti-conception will be included in this study.
* Between 18 and 35 years of age.
* Predominant right-handedness.
* Normal or corrected-to-normal vision
* Normal uncorrected hearing
Exclusion criteria
* Metal objects in or around the body (e.g., braces, pacemaker, metal fragments, insulin pump, and hearing devices).
* History of psychiatric treatment or current psychiatric treatment.
* History of neurological treatment or current neurological treatment.
* Claustrophobia.
* Epilepsy.
* Pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL43437.091.13 |