Objective: The main objective of the study is to compare the antispasmodic effect of two calcium channel blocker (verapamil and nicardipine) on the prepared radial artery conduit.
ID
Source
Brief title
Condition
- Vascular therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints: The main endpoint of the study is the mean
amount of free flow through the radial artery conduit. This is measured
directly after harvesting the radial artery by allowing a free flow of both
solution through the conduit into an empty bowl. The mean amount of the
solution (in ml) collected in one minute is calculated. This is considered as
the mean free flow (ml/min) through the conduit.
Secondary outcome
none
Background summary
Rationale: The use of topical application of vasodilators such as calcium
channel blockers and/or nitroglycerines leads to possible improvement of the
blood flow via the radial artery conduit by avoiding perioperative spasm.
Study objective
Objective: The main objective of the study is to compare the antispasmodic
effect of two calcium channel blocker (verapamil and nicardipine) on the
prepared radial artery conduit.
Study design
Study design: A prospective randomized non-blind mono-centre study
Intervention : After harvesting the radial artery and before performing the
anastomoses, topical application of two different vasodilator solutions will be
performed. One solution is being used in the standard practice of our
department and contains 10 mg verapamil. In the other solution, verapamil is
replaced by nicardipine (10 mg).
Study burden and risks
not applicable
Michelangelolaan 2
Eindhoven 5623EJ
NL
Michelangelolaan 2
Eindhoven 5623EJ
NL
Listed location countries
Age
Inclusion criteria
Patients undergoing isolated or combined CABG whereby the radial artery is used as a conduit with or without the use of other conduits.
Exclusion criteria
Emergency operations
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44701.060.13 |