Measurement of the pain index, NoL, during laryngoscopy, intubation and skin incission during variations in de level of propofol and remifentanil.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
patienten die een elective chirurgische ingreep ondergaan onder algehele anesthesie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
NoL
Secondary outcome
Cardiovascular parameters incl. HR, BP and CO
Background summary
Despite various efforts there is still the need for adequate monitoring of pain
and nociception during anesthesia. In our previous protocol we measured pain
responses during anesthesia based on single end-points, eg heart rate, blood
pressure and pulse transit time. None of these parameters provided sufficient
information regarding nociception. We therefore want to further investigate
this matter using a composite parameter, the Nociception Level or NoL. The NoL
is a novel index that measures the magnitude of the autonomic response to
painful stimuli. The NoL combines information from several physiological
parameters, which represent different autonomic pathways. The multi-parameter
approach empowered with state-of-the-art signal processing and machine learning
techniques. The NoL has been shown to have strong association with intensity of
the pain stimuli.
Study objective
Measurement of the pain index, NoL, during laryngoscopy, intubation and skin
incission during variations in de level of propofol and remifentanil.
Study design
Observational
Study burden and risks
We expect no study related side effect. Anesthesia related side effects include
hypo/hypertension, brady/tachycardia
Albinusdreef 2
Leiden 2333 ZA
NL
Albinusdreef 2
Leiden 2333 ZA
NL
Listed location countries
Age
Inclusion criteria
Patients undergoing elective surgery under general anesthesia
Exclusion criteria
Age: < 18 or > 80 years;
Unable to give written informed consent;
Pregnancy/lactation;
Extreme obesity: BMI > 35;
Perceived difficult intubation.
Patients requiring a rapid sequence induction
Patients on beta-blockers
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL43511.058.13 |
| OMON | NL-OMON24176 |