To obtain normal values for speckle-tracking derived parameters and for biomarkers in healthy volunteers aged from 20 till 70 years.
ID
Source
Brief title
Condition
- Cardiac disorders, signs and symptoms NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Determining normal values of LV and RV radial, circumferential and longitudinal
strain, and LV rotation and twist by speckle-tracking echocardiography in
various age groups.
Secondary outcome
Determining normal values of the biomarkers NT-proBNP, hsCRP, hsTnT, IL-1,
IL-6, TNF-α, MMP-2, MMP-9, TIMP-1, GDF-15, HSP-70 in various age groups.
Background summary
Conventional two-dimensional echocardiography is a valuable tool in cardiology,
especially for the assessment of global systolic and diastolic function in for
instance patients with congenital heart disease or cardiomyopathy. The most
widely used parameter for describing left ventricular (LV) systolic function in
a clinical setting is fractional shortening. However, fractional shortening
only measures LV systolic function along a single interrogation line,
potentially missing regional systolic dysfunction. The right ventricle (RV) is
even more difficult to visualize and quantify. Recent advances in
echocardiography have lead to the development of techniques that measure global
and regional myocardial function more accurately than the conventional
echocardiography. The so-called speckle-tracking 2D-echocardiography and
3D-echocardiography provide much more accurate information on tissue
deformation, such as myocardial strain and strain rate (SR). There are various
vendors for these ultrasound systems and software. Other new and possibly
additional measurements are the new biomarkers. These could be used to monitor
subtle molecular changes in the heart that reflect and possibly predict adverse
changes before they become clinically apparent. At present, normal values for
biomarkers and speckle-tracking derived strain measured with the software used
in our hospital are scarce, which hampers the interpretation of these values in
patients with heart disease.
Study objective
To obtain normal values for speckle-tracking derived parameters and for
biomarkers in healthy volunteers aged from 20 till 70 years.
Study design
A prospective, observational cohort study.
Study burden and risks
Echocardiography and venous punction are routinely performed in Erasmus MC.
Echocardiography is a non-invasive imaging technique; venous punction is
invasive, but minimally and will be performed by experienced employees. There
are no known significant safety issues.
's-Gravendijkwal 230
Rotterdam 3015 CE
NL
's-Gravendijkwal 230
Rotterdam 3015 CE
NL
Listed location countries
Age
Inclusion criteria
Healthy adults between the age of 20 and 70 years.
Capable of understanding and signing informed consent.
Exclusion criteria
Cardiovascular disease.
Cardiovascular risk factors, such as hypertension, diabetes mellitus, hypercholesterolaemia.
Non-Dutch speaking.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL45681.078.13 |