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LONG-TERM FOLLOW-UP OF HBEAG-POSITIVE CHRONIC HEPATITIS B PATIENTS TREATED WITH INTERFERON ALFA: RELATION TO POLYMORPHISMS IN IL28B AND APOLIPOPROTEIN E LOCI (INTERFERLONG STUDY)

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investigate the relationship between il28b and apolipoproteine E genotype and response to interferon

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Ethical review
Approved WMO
Status
Pending
Health condition type
Hepatic and hepatobiliary disorders
Study type
Observational invasive

ID

NL-OMON39063

Source

ToetsingOnline

Brief title

Response to interferon in hepatitis B: relation to IL28b and Apo E

Condition

  • Hepatic and hepatobiliary disorders
  • Viral infectious disorders

Synonym

chronic hepatitis B, liver inflammation

Research involving

Human

Sponsors and support

Primary sponsor :
Academisch Medisch Centrum
Source(s) of monetary or material Support :
Stichting leveronderzoek

Intervention

Keyword :
Apolipoprotein E, chronic hepatitis B, IL28b, interferon

Outcome measures

Primary outcome

IL28b & Apo E genotype --> HBeAg and HBsAg loss.

Secondary outcome

-

Background summary

interferon is an effective treatment for chronich hepatitis B. Unfortunately,
only a limited number of patients achieves a response to interferon. IL28b and
apolipoprotein E genotypes may predict response.

Study objective

investigate the relationship between il28b and apolipoproteine E genotype and
response to interferon

Study design

cross-sectional

Study burden and risks

minimal

Public
Academisch Medisch Centrum

's Gravendijkwal 230
Rotterdam 3015CE
NL
Scientific
Academisch Medisch Centrum

's Gravendijkwal 230
Rotterdam 3015CE
NL

Listed location countries

Netherlands

Age

Adults (18-64 years)
Elderly (65 years and older)

Inclusion criteria

chronic hepatitis B
treated with interferon

Exclusion criteria

coinfections with HIV, HCV

Design

Study type :
Observational invasive
Masking :
Open (masking not used)
Control :
Uncontrolled
Primary purpose :
Treatment

Recruitment

NL
Recruitment status
:
Pending
Start date (anticipated) :
Enrollment :
135
Type :
Anticipated

Approved WMO
Date :
Application type :
First submission
Review commission :
METC Erasmus MC, Universitair Medisch Centrum Rotterdam (Rotterdam)

Followed up by the following (possibly more current) registration

No registrations found.

Other (possibly less up-to-date) registrations in this register

No registrations found.

In other registers

Register ID
CCMO NL32192.078.10