The aim of this study is to find out whether TIG and revaccination prescription is in accordance with the immune status of a patient as measured by the TQS. Furthermore, the objective is to assess whether or not the TQS might be of additional value…
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Immune status as a result of the TQS and as a result of the anamnestic
vaccination history.
The percentage under- and overprescription of tetanus prophylaxis in the
different age groups with and without adequate tetanus antibody levels as
determined by the TQS.
Secondary outcome
Not applicable
Background summary
Tetanus is a serious infectious disease, which can be lethal without treatment.
Routine vaccination in the the National Immunization Programme with high
vaccination coverage, has resulted in very high seroprevalence of tetanus
antibodies in the Dutch population. Each year only about 2 to 3 cases of
tetanus are reported. Almost all of these cases occur among not (fully)
immunized elderly people who have not been eligble for routine vaccination.
After wounding, people without a sufficient vaccination status can be protected
by the administration of tetanus immunoglobulin (TIG) and/or (re)vaccination.
The high seroprevalence implicates that tetanus toxoid (TT) is given often to
individuals that are already protected. On the other hand their are certain
groups (i.e. people too old to be eligible for vaccination) who have lower
seroprevalence and recently some cases were notified among this group whom have
not been given TIG. The indication for (re)vaccination and TIG are complicated
since health care personel has to rely on self-reported vaccination history
that might not be reliable. Recently the Tetanus Quick Stick (TQS) has become
available. This instrument might help to decide whether a patient is at risk
for contracting tetanus.
Study objective
The aim of this study is to find out whether TIG and revaccination prescription
is in accordance with the immune status of a patient as measured by the TQS.
Furthermore, the objective is to assess whether or not the TQS might be of
additional value in decision making for prophylaxis for specific age groups.
Study design
Cross-sectional study
Study burden and risks
Participating in this clinical research, will extend the visit at the ED with
a few minutes. Participants will not suffer from a different risk compared to
people who are not participating, because they will receive routine care. Main
benefit is that when people have low level of antibodies as measured by the TQS
while based on the reported vaccination status TIG and/or (re)vaccination were
not indicated they will receive proper prophylaxis and therefore will
adequately protected against tetanus. .
Antonie van Leeuwenhoeklaan 9
Bilthoven 3721 MA
NL
Antonie van Leeuwenhoeklaan 9
Bilthoven 3721 MA
NL
Listed location countries
Age
Inclusion criteria
- Participants need to be at least 18 years old.
- Participants with all types of wounds visiting one of the three emergency departments.
Exclusion criteria
- Patients younger than 18 years old.
- Patients with severe injuries requiring immediate care or surgery
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL39940.100.12 |
| Other | NTR13149 |
| OMON | NL-OMON23665 |