To study the relation between face processing and activation in cortical pathways in adults with Autism Spectrum Disorder.
ID
Source
Brief title
Condition
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Brain activity will be measured using Electroencephalography (EEG). Special
interest will be in activity related to:
- face processing (negative peak approximately 170 ms after stimulus
presentation)
- feedforward pathway activation
- feedback pathway activation
- horizontal pathway activation
Secondary outcome
Behaviour will be measured in two tasks during the visual perception experiment:
A. Categorization of faces, houses, objects, and stimuli containing lines
B. Categorization of characteristics of a circle, which will be presented along
with the faces, houses, objects, and stimuli containing lines
Background summary
For typically developed persons, faces hold important social and biological
information, which is crucial in social behaviour and communication. Different
aspects of face processing, i.e. face categorization and perception, require
differential activation in cortical pathways in the visual cortex. These
pathways seem to be activated abnormally in persons with Autism Spectrum
Disorder, where some aspects of face processing are impaired as well. The
current study aims to investigate how activation in cortical pathways is
related to face processing in ASD.
Study objective
To study the relation between face processing and activation in cortical
pathways in adults with Autism Spectrum Disorder.
Study design
An observational study with a between- and within-subject design, with a
comparison between adults with and without Autism Spectrum Disorder. Adults
will participate once in a visual perception task at the University Medical
Centre (UMC) Utrecht. During the task, behaviour and electrical brain
activation will be registered.
Study burden and risks
Participants do not directly benefit from the research project. The risk of
participation is neglectable, and the burden is minimal; it will take 2-5 hours
(dependent on the available diagnostic information) and, on request, the
participant can visit our lab twice. Research is group related, meaning that
the research question can not be answered without participation of the
population to which the research question is applicable (patients with Autism
Spectrum Disorder).
Heidelberglaan 2
Utrecht 3584 CS
NL
Heidelberglaan 2
Utrecht 3584 CS
NL
Listed location countries
Age
Inclusion criteria
Healthy participants: Healthy adults
Patients: Adults, with a diagnosis of Autism Spectrum Disorder, being diagnosed by a registered medical professional at the UMC Utrecht.
Exclusion criteria
Healthy participants: a diagnosis of Autism Spectrum Disorder or any other type of psychiatric disorder
Patients: diagnosis of any type of psychiatric disorder, except of Autism Spectrum Disorder; use of medication
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL33256.041.10 |