To demonstrate differences in neuronal structure and neuronal function in brain regions that control eating behaviour between obese and normal weight adolescents.
ID
Source
Brief title
Condition
- Appetite and general nutritional disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Structural MRI of brain areas involved in eating behaviour
2. Functional MRI resting state
3. Functional MRI passive visual stimulus, emotional inhibition and backward
masked stimulus
Secondary outcome
Not applicable
Background summary
The prevalence of overweight and obesity among children is alarming high.
Childhood obesity is associated with serious health risks. Obesity is the
result of a disturbed balance between energy intake and expenditure. The brain
is the central regulator of energy balance. Brain areas that play crucial roles
in eating behaviour are the hypothalamus, the mesolimbic dopamine system and
the prefrontal cortex. Several imaging studies have revealed the complexity of
the human brain mechanisms related to eating behaviour. The exact
neuropathophysiological mechanisms underlying obesity are unclear. This
(functional) magnetic resonance imaging ((f)MRI) study might be helpful to
disentangle these mechanisms underlying childhood obesity, a predictor of adult
obesity. In addition, these results might offer the opportunity to develop
novel therapeutic targets.
Study objective
To demonstrate differences in neuronal structure and neuronal function in brain
regions that control eating behaviour between obese and normal weight
adolescents.
Study design
Case-control study
Study burden and risks
After comprehensive explanation (written and oral) to participants, (f)MRI
scanning will be no burden and acceptable to these adolescents as described in
the notice *Toetsingskader niet-therapeutisch MRI-onderzoek bij minderjarige en
wilsonbekwame proefpersonen* from The Central Committee on Research Involving
Human Subjects (CCMO, 2004) (www.ccmo.nl).
Albinusdreef 2
Leiden 2333 ZA
NL
Albinusdreef 2
Leiden 2333 ZA
NL
Listed location countries
Age
Inclusion criteria
Obesity (cases) and normal-weight (controls) BMI conform cut-off points according to Cole (2000)
12-16 years old
Caucasian origin
Exclusion criteria
Obesity due to medical cause (excluding using standard protocol)
Unremovable metal devices
Weight-loss intervention program during study participation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31540.058.10 |