We aim to document the brain anatomy and functioning and development of children and adolescents of different ages who suffer from Prader-Willi syndrome in order to gain insight into the possible relation between the observed behavior and the brain…
ID
Source
Brief title
Condition
- Chromosomal abnormalities, gene alterations and gene variants
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We will measure multiple parameters such as total brain volume, grey
matter/white matter volume, volumes of various brain structures (such as
pituitary gland, caudate nucleus, hippocampus, hypothalamus), white matter
connections (corpus callosum, anterior and posterior commisures), connectivity
within the different lobes. We will further investigate the known functional
networks within the brain by means of resting state fMRI. Longitudinal changes
in structure and function will be assessed as well.
Secondary outcome
not applicable
Background summary
Brain structure and development in children and adolescents with Prader-Willi
syndrome: a combined structural and functional MRI study
In the previous studies within our group we gathered a lot of data about
children and adolescents with Prader-Willi syndrome, such as weight, length,
endocrine markers, sleep disturbances which has led to the improvement of the
treatment of children and adolescents with Prader-Willi syndrome. However,
until now there were no studies conducted that addressed the anatomy and
development of the brain of children and adolescents with Prader-Willi
syndrome.
Study objective
We aim to document the brain anatomy and functioning and development of
children and adolescents of different ages who suffer from Prader-Willi
syndrome in order to gain insight into the possible relation between the
observed behavior and the brain anatomy.
Study design
Observational/comparative longitudinal study
Study burden and risks
The risks associated with MRI research are not reported yet and the burden
caused by MRI noise is minimized.
Westzeedijk 106
Rotterdam 3016AH
NL
Westzeedijk 106
Rotterdam 3016AH
NL
Listed location countries
Age
Inclusion criteria
Children and adolescents with genetically confirmed PWS and known genetic defect between 6-25 years old and healthy age- and sex-matched controls
Written Informed consent of the caregivers and children and adolescents older than 12 years and assent of patients/children younger than 12 years
Written informed consent of healthy adult controls
Successful completion of the mock MRI scanner protocol for healthy controls under 12 years old
Exclusion criteria
Other chromosomal abnormalities
Claustrophobia
Contra-indications for MRI scanner
The use of medication for treating anxiety, mood disorders or psychiatric disturbances including the regular use of homeopathic St John*s wort preparations for longer than two weeks
Expected or proven non-compliance
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32706.078.10 |