1) to investigate cognitive functioning in lacunar infarct patients with and without periventricular white matter lesions; 2) to identify predictors for cognitive dysfunction in lacunar infarct patients.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
- Cognitive and attention disorders and disturbances
- Vascular injuries
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cognitive function based on several (neuro)psychological domains: information
processing speed, attention/concentration, executive functioning, memory and
language. Raw test scores will be used for analyses.
Presence/ progression WMLs.
Secondary outcome
Brain Microbleeds.
Other cerebral abnormalities observed by MRI: atrophy and other cerebral
abnormalities.
Background summary
Rationale: around a quarter of the yearly 24 to 25 thousand new patients with a
brain infarct suffers from a so-called lacunar stroke: a small, deeply located
brain infarct caused by a local abnormality in the small arteries (cerebral
small vessel disease, SVD). Previous research found cognitive impairment in
these patients. However, the exact cause of this SVD-mediated cognitive decline
is not clear. Also, factors influencing and predicting the course of cognitive
functioning have not yet been identified. Recent studies suggest that
endothelial dysfunction may play a role.
Study objective
1) to investigate cognitive functioning in lacunar infarct patients with and
without periventricular white matter lesions;
2) to identify predictors for cognitive dysfunction in lacunar infarct
patients.
Study design
Prospective, observational, follow-up cohort study.
Study burden and risks
Patients undergo non-invasive magnetic resonance imaging (MRI) of the brain and
a neuropsychological assessment.
P.Debyelaan 25
Maastricht 6229 HX
NL
P.Debyelaan 25
Maastricht 6229 HX
NL
Listed location countries
Age
Inclusion criteria
- First lacunar infarct, diagnosed clinically as well as radiologically.
- Age of 18 years and older.
Exclusion criteria
- Brain infarct or other cerebral pathology in recent history.
- Potential source of cardio-embolism or carotic stenosis (large vessel disease)
- Severe comorbidity (specified as not being able to perform Activities of Daily Living (ADL independently)), including dementia.
- Limited life-expectancy
- History of inflammatory disease
- Contra indications for MRI
o Heart valve prosthesis
o Pacemaker
o Intracerebral clips (aneurysm)
o Intra-ocular metal pieces
o Cochlear implant
o Claustrophobia
- When the patient does not appreciate to receive the results of the study, in particular if abnormalities are found during MRI or neuropsychological assessment, which are of great importance for the patients health.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26933.068.09 |