Our primary objective is to investigate the development of structural and functional connectivity in autism and ADHD in comparison to the typical development of connectivity. A secondary objective is to investigate the effects of ADHD and autism…
ID
Source
Brief title
Condition
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary endpoints of this study are developmental changes in structural and
functional brain connectivity. The measures of interest are resting-state
functional connectivity, as assessed with resting-state functional Magnetic
Resonance Imaging (rs-fMRI), myelination as assessed with Magnetization
Transfer Imaging (MTI), and white matter integrity, as assessed with
track-based Diffusion Tensor Imaging (DTI)-measures.
Secondary outcome
An exploratory analysis of the effect of genotype on shared risk genes for
autism and ADHD will be conducted and symptoms of ADHD and ASD from symptom
rating scales and performance on computerized tasks will be analyzed
Background summary
Recent MR-research has shown that brain connectivity changes over development.
Furthermore, it appears that child psychiatric disorders may be associated with
changes in connectivity. This protocol investigates structural and functional
connectivity in children with child psychiatric diagnoses, in particular Autism
Spectrum Disorders (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD).
Study objective
Our primary objective is to investigate the development of structural and
functional connectivity in autism and ADHD in comparison to the typical
development of connectivity. A secondary objective is to investigate the
effects of ADHD and autism risk genes on brain connectivity in these disorders.
Study design
We propose to conduct a longitudinal MR-study to investigate the development of
brain connectivity in ADHD and autism.
Study burden and risks
Participants will be asked to undergo an MRI-scan lasting approximately 45
minutes. DNA will be collected from saliva. MRI is a non-invasive technique,
with no known risks associated with it. Subjects will be prepared for
MR-scanning using an MR-simulation procedure. Incidental findings of structural
cerebral pathology requiring medical treatment may occur. If this happens, the
subject and his/her parents will be notified. No immediate benefits for
subjects are to be expected from participation in this study. In the long run,
increased understanding of the aetiology and pathophysiology of child
psychiatric disorders may contribute to earlier diagnosis, and earlier
detection and/or prediction of treatment outcome.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
General inclusion criteria for all subject groups
• Aged 6 through 18 years at initial inclusion
• Ability to speak and comprehend Dutch (both participant and parent).;Inclusion criteria for subjects with autism
• DSM-IV (APA, 1994) diagnosis of autism, supported by ADI-R interview;Inclusion criteria for subjects with ADHD
• DSM-IV (APA, 1994) diagnosis of ADHD, supported by DISC interview ;Inclusion criteria for control subjects
• No DSM-IV (APA, 1994) diagnosis, supported by DISC interview
• No history of psychiatric illness in first degree family members of the subjects
Exclusion criteria
1) Mental retardation (IQ < 70)
2) Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
3) Presence of metal objects in or around the body (pacemaker, dental braces)
4) History of or present neurological disorder
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL33864.041.11 |