To establish the effect of an adapted form of MCT (MCT-a) on paranoid ideation and cognitive insight in patients with recent onset psychotic symptoms.
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main outcome measures are
1) paranoid ideation as measured with the Green Achterdochtige Gedachten Schaal
(GAGS), a validated Dutch version of the Green Paranoid Thought Scales (GPTS)
(Green et al., 2008);
2) cognitive insight as measured with the Beck Cognitive Insight Scale (BCIS).
3) psychotic symptoms and general symptoms, as measured with the Positive and
Negative Syndrome Scale (PANSS) (Kay, Lewis & Fiszbein, 1987) and with
experience sampling (Palmier-Claus et al., 2011)
4) Client satisfaction, as measured with the Client Satisfaction
Questionnaire-8 (CSQ-8) (de Brey, 1983).
5) Feasibility of the training as measured with the Client Evaluation
Questionnaire (CEQ).
Secondary outcome
1) "Jumping to conclusions (JTC)" as measured with the Beadstest (Huq, Garety,
& Hemsley, 1988).
2) "Attribution bias" as measured with the Internal, Personal, and Situational
Attributions Questionnaire (IPSAQ, Kinderman and Bentall 1996)
3) Psychotic symptoms and dthe distress caused by them as measured with the
Community Assessment of Psychic Experiences (CAPE)
4) "Theory of mind" - a social cognition task- as measured with the Hinting
Task (Corcoran et al. 2005).
5) "Theory of mind" as measured with the Degraded Facial Affect Recognition
(van't Wout et al., 2004, 2007).
6) Metacognition, as measured with the Metacognitions Questionnaire (Wells &
Cartwright-Hatton, 2004).
Background summary
Meta-analyses suggest that cognitive interventions are effective in
ameliorating symptoms of psychosis. Cognitive biases, such as jumping to
conclusions, are likely to be involved in the pathogenesis of paranoid ideation
and psychosis. A recently developed group program, called meta cognitive
training (MCT), aims to target these biases.
Study objective
To establish the effect of an adapted form of MCT (MCT-a) on paranoid ideation
and cognitive insight in patients with recent onset psychotic symptoms.
Study design
Randomised controlled study with occupational therapy as an active control
condition.
Intervention
MCT is a hybrid of psycho education, cognitive remediation and
cognitive-behavioural therapy. The training consists of 8 sessions of 45
minutes, and will be given once a week. We adapted a group-based protocol for
patients with recent onset psychosis by introducing specific homework
assignments based on MCT +, an individualized MCT program, in order to target
cognitive biases and to enhance generalisation of treatment effect. The control
group receives 45 minutes of occupational therapy; a group-based therapy in
which effective functioning and skills in relation to daily life and work are
addressed.
Study burden and risks
Expected risk of participation in the study is negligible; the intervention
will be part of the treatment program of patients admitted to a recent
psychosis ward; No physical examinations of discomfort are expected related to
study participation.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet the following criteria: recently developed schizophrenia or related disorder and an age between 18 and 35.
Exclusion criteria
Patients scoring 6-7 on the PANSS positive subscales (patients suffering from serious positive symptoms that interfere with their daily functioning) are excluded as this is considered detrimental for group training.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL42590.018.12 |