This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Blood oxygenation level dependent (BOLD) response in dorsal frontal-striatal
and cortico-cortical systems in PD patients and controls, compared to their
BOLD response as measured during the initial testing session.
Secondary outcome
secundary study parameters:
1) Differences in BOLD responses across differnet cognitive and psychiatric
symptom-related subgroups in PD patients.
2) Structural abnormalities in PD versus controls, using:
a) voxel-based morphometry (VBM): measure for regional volumetry
b) diffusion tensor imaging (DTI): measure for structural connectivity
3) Resting state functional connectivity in PD versus controls, focussing on:
a) cortico-cortical connections
b) cortico-subcortical connections
4) Differences in functional and structural measures between the initial and
the current testing session
Background summary
The frontal-striatal system mediates emotional and cognitive processes.
Parkinson*s Disease (PD), shows abnormalities of the frontal-striatal system,
leading to a dysregulation of cortico-cortical systems and emotional and
cognitive symptoms.
Study objective
This project aims to understand the symptomatology PD in the light of
functional brain interactions, in the hope of elucidating the role of the
frontal striatal system to behaviour.
Study design
Participants will be invited back to the VUmc for a shortened follow-up
investigation, on two days.
- Day 1: Psychiatric questionnaires and neuropsychological tests; practicing
the tasks for day 2.
- Day 2: undergoing an MEG scan (eyes open/eyes closed, 5 minutes each) and an
MRI scan (Stop task, delay discounting task, anatomical scan, DTI scan,
spectroscopy scan, resting state scan; together 50 minutes)
Intervention
Repetitive transcranial magnetic stimulation (rTMS) will be used to temporarily
enhance the excitability of the dorsal prefrontal cortex in patients and, in
contrast, to temporarily reduce dorsal responsiveness in healthy controls.
Study burden and risks
Participants will visit the VUmc during 2 separate days.
Day 1: 2 hours psychiatric and neuropsychological assessment
Day 2: 20 minutes Magnetoencephalography (MEG) scan session and 50 minutes MRI
scan session during rest and during cognitive tasks.
van der Boechorststraat 7
Amsterdam 1081BT
NL
van der Boechorststraat 7
Amsterdam 1081BT
NL
Listed location countries
Age
Inclusion criteria
idiopathic PD, 40-65yo
Exclusion criteria
psychotropic medication
epilepsy
metal in body
pregnancy
other neurological disease
major somatic disorders
severe claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL23621.029.08 |