Evaluation of long-term position, volume and FDG-uptake of the orchidopexied testis because of congenital undescended testis.
ID
Source
Brief title
Condition
- Endocrine gland therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- FDG-uptake testes (PET-CT-scan)
- SUV max/mean
- laterality-index left/right testes
Secondary outcome
- testis position
- testis volume as measured by ultrasound
- testis volume as measured by PET-CT-scan
- correlations above mentioned
Background summary
Long-term consequences of orchidopexy for congenital undescended testis on
fertility are hardly known. Partly, this is because evaluation of the seperate
function of both testes is difficult.
The PET-CT-scan, which shows the FDG-uptake (parameter for metabolism) of both
testicles apart from each other, seems a promosing research on the funtion of
the testis after orchidopexy.
We hypothesise the orchidopexied testis has a lower metabolism than the
contralateral testis and lower than the testis in men of the general
population.
Study objective
Evaluation of long-term position, volume and FDG-uptake of the orchidopexied
testis because of congenital undescended testis.
Study design
long-term follow-up study
Study burden and risks
Men will be requested to participate in the study and visit the MCA once to
receive
- a short questionnaire
- physical examination
- ultrasonographic examination
- PET-CT-scan
The short questionnaire, physical and ultrasonographic examination are
painless, without any risks and will take a quarter of an hour.
Adverse effects of the PET-CT are not expected. The PET-CT has a certain
radiation burden since every radiation is potentially harmful. However,
concerning radioactive exposure, the study protocol is designed according to
the ALARA principle (As Low As Reasonably Achievable). For a 75 kg man the
radiation burden will approximately be 2 mSv (whereas for a regular PET-CT, the
radiation burden is between 6-10 mSv).
Wilhemlminalaan 12
Alkmaar 1815 JD
NL
Wilhemlminalaan 12
Alkmaar 1815 JD
NL
Listed location countries
Age
Inclusion criteria
- orchidopexy because of congenital undescended testis between 1984 and 1994 in the Medical
Centre of Alkmaar
- signed informed consent form.
Exclusion criteria
- other testicular abnormality, currently or in past
- not yet reached puberty stage 5 according to Tanner
- diabetes
- incontinence
- kidney failure
- participation in a medical experiment in which radioisotopes were administered in the previous 12 months
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL42125.094.12 |