The study*s objective is to measure neurobiological differences between veterans and military men with aggression regulation problems after deployment and healthy control participants.
ID
Source
Brief title
Condition
- Other condition
- Impulse control disorders NEC
Synonym
Health condition
agressieregulatie problematiek
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Differences in amygdala and prefrontal cortex activity, differences in startle
response, differences in blood parameters as neuropeptide Y, vasopressin and
testosterone, differences in performance on neuropsychological tasks between
veterans with aggression regulation problems and healthy control participants.
Secondary outcome
n.a.
Background summary
Aggression regulation problems are a common complaint after deployment, however
the underlying neurobiology of aggression regulation problems remains unknown.
This study aims to examine which neurobiological abnormalities are associated
with aggression regulation problems.
Study objective
The study*s objective is to measure neurobiological differences between
veterans and military men with aggression regulation problems after deployment
and healthy control participants.
Study design
This study is a cross-sectional study with inclusion of a control group.
Study burden and risks
The burden and risks of this study are: (1) 36 ml of blood will be drawn from
the participants, (2) An MRI scan can be perceived as uncomfortable, (3) the
psychological questionnaires and interviews can evoke unwanted feelings.
Considering the objective and relevance of this study, this burden is evaluated
as negligible.
Heidelberglaan 100
Utrecht 3584CX
NL
Heidelberglaan 100
Utrecht 3584CX
NL
Listed location countries
Age
Inclusion criteria
For participants with impulsive aggression, the following inclusion criteria:
- Soldiers and veterans (men) who participated in a military deployment (minimum 4 months)
- Age between 18 and 50 years
- Presence of problems with aggression as evidenced by either (I): the A1 or A2 criterion of the research diagnostic criteria for impulsive aggression "(Coccaro, 2012), or (II) evidence for problems with pent-up anger as revealed by answers to the screening questionnaire.
- Written informed consent; For control participants, the following inclusion criteria:
- Healthy men
- Age between 18 and 50 years
- Written informed consent
- No (current) DSM-IV Axis-I disorder
- No evidence of problems with aggression
Exclusion criteria
- Alcohol / substance abuse and / or dependence
- Severe neurological diseases (eg Parkinson's disease, stroke, MS);Exclusion for MRI procedure:
- Claustrophobia, pacemaker (or other implants), or metal objects in the body causing an MRI scan is not possible.
- Current use of psychotropic drugs (benzodiazepines, antidepressants, antipsychotics, anticonvulsants)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL42537.041.12 |