The objective of the current experiment is to validate cognitive- and EEG-diagnostic markers of ADHD-symptoms by studying differences in cognitive task performance between subjects diagnosed ADHD, undiagnosed ADHD subjects showing ADHD symptoms and…
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters will be Stop-signal reaction time on the stop-signal
task and the P300 ERP component during that task.
Secondary outcome
The following secundary parameters will be taken into account:
• Task-switching test: switch costs;
• Choice delay test: percentage long-delay awards;
• Verbal memory: immediate recall, delayed recall and recognition;
• Continuous Performance Task: commission errors;
• EEG: P300 ERP during all tasks except the choice-delay task.
Background summary
ADHD can only be diagnosed based on observable behaviour criteria. However,
because of the aetiology of ADHD, it is expected that ADHD patients perform
worse on cognitive tests and show differences in ERP components during those
tasks, as compared to healthy adults. In the current study, it will be examined
to which extent cognitive tests and ERP measurements can enhance ADHD diagnosis
accuracy.
Study objective
The objective of the current experiment is to validate cognitive- and
EEG-diagnostic markers of ADHD-symptoms by studying differences in cognitive
task performance between subjects diagnosed ADHD, undiagnosed ADHD subjects
showing ADHD symptoms and healthy subjects showing no ADHD symptoms at all.
Cognitive tasks will be assessed, while simultaneously recording brain
activity.
Study design
This study will be conducted according to a mixed model design.
Study burden and risks
The time investment for the participants will be around 6 hours in total,
spread over one training session and two subsequent sessions of testing on
different days.
Universiteitssingel 40
Maastricht 6229 ER
NL
Universiteitssingel 40
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
In addition to the inclusion and exclusion criteria valid for all groups, some criteria are specifically valid for one group only.
Inclusion criteria for all groups:
- Male or female;
- Ages between 18 and 35 years of age;
- Willingness to sign an informed consent.;Inclusion criteria ADHD+ group specific
- Meeting DSM-IV criteria for an ADHD-diagnosis.;Inclusion criteria ADHD± group specific
- Showing ADHD symptoms, but not sufficient for the diagnosis.
Exclusion criteria
Exclusion criteria for all groups
- Use of recreational drugs in the past month;
- Excessive drinking;
- Pregnancy;
- Use of ADHD medication in the past.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38839.068.11 |