To find out if the mean thyroid volumes of healthy 10-12 and 17-18 years old Dutch children and adolescents are the same or larger than in the late nineteen nineties, and if the dietary iodine intake of these children and adolescents has decreased…
ID
Source
Brief title
Condition
- Thyroid gland disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Thyroid volume (measured by ultrasonography) and calculated dietary iodine
intake (based on measured iodine excretion in a 24 hours urine collection and a
short, structured dietary history).
Secondary outcome
Not applicable.
Background summary
Correct judgement of a measured thyroid volume of a child or adolescent as
either too low or too high requires accurate normative values. The one and only
study establishing normative values carried out in the Netherlands dates from
the late nineteen nineties. In this study, 937 children and adolescents living
in the eastern and western parts of the Netherlands underwent thyroid
ultrasonography, measurement of urinary iodine excretion and analysis of
dietary iodine intake. Besides providing normative values, it was concluded
that the dietary iodine intake of Dutch children and adolescents was
sufficient. However, dietary habits are changing. In a recent study by the RIVM
it was found that since 2008 dietary iodine intake in the Netherlands has
decreased by 20 tot 25%. This decrease may result in suboptimal thyroid hormone
production and thyroid enlargement. With this in mind, we wondered if thyroid
glands of children and adolescents living in the Netherlands now are larger
than in the late nineteen nineties. We also wondered if their iodine intake is
measurably lower than in the late nineteen nineties.
Study objective
To find out if the mean thyroid volumes of healthy 10-12 and 17-18 years old
Dutch children and adolescents are the same or larger than in the late nineteen
nineties, and if the dietary iodine intake of these children and adolescents
has decreased compared to the late nineteen nineties.
Study design
We plan to conduct an observational study in which we want to measure thyroid
volume (by ultrasonography) and calculate dietary iodine intake (by measuring
iodine excretion in a 24 hours urine collection and taking a short, structured
dietary history). Two well-trained high school students, supervised by one of
the principal investigators, will carry out the ultrasonographies.
Study burden and risks
Given the fact that neck ultrasonography is a harmless procedure, the risks
associated with participation can be considered negligible and the burden can
be considered minimal. The results of this study will provide important
information with regard to the usefulness of the normative data on the thyroid
size of Dutch children gathered in the late nineteen nineties. In addition it
will provide an answer to the question if dietary iodine intake is still
sufficient.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
Healthy 10-12 years old children and 17-18 years old adolescents attending two primary and one secondary school in the city of Leiden.
Exclusion criteria
-a diagnosis of congenital or acquired thyroid disease.
-thyroid medication, like thyroid hormone or thyrostatic drugs (thiamazol or prpopylthiouracil).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL42839.018.12 |