To test the hypothesis that the resonant frequencies in the basilar membrane in the inner ear are shifted upward while using Carbamazepine.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Het onderzoek heeft geen betrekking op een aandoening, maar op het normale gehoor
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Shift of SOAE frequencies, related to Carbamazepine usage.
Secondary outcome
N/A
Background summary
Carbamazepine is known to affect pitch perception. Patents with absolute pitch,
that use Carbamazepine, describe that the pitch of musical instruments is too
low while they are using the drug. We hypothesize that Carbamazepine results in
an upward shift of the resonance frequencies of the basilar membrane in the
inner ear.
Study objective
To test the hypothesis that the resonant frequencies in the basilar membrane in
the inner ear are shifted upward while using Carbamazepine.
Study design
Spontaneous otoacoustic emissions will be recorded in patients that start or
stop using carbamazepine, as advised by their physician. There will be a SOAE
registration both when they are using, and when they are not using the drug,
respectively. In addition, there will be standard tone audiometry.
Study burden and risks
Their are no risks involved in study participation. There will be two
measurement sessions. The total length of each session is 20 minutes.
Measurement do not require significant effort by the participant. Study
participation does not have advantages or disadvantages for the subjects.
Hanzeplein 1
Groningen 9712 GZ
NL
Hanzeplein 1
Groningen 9712 GZ
NL
Listed location countries
Age
Inclusion criteria
- 18 * age * 45
- normal hearing
- detectable spontaneous otoacoustic emissions in at least one ear
- patients that use carbamazepine and have been advised to stop using the drug, or patients that are advised to start using the drug.
Exclusion criteria
No detectable spontaneous otoacoustic emissions
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40441.042.12 |