To determine if SS improves motor learning and transfer of a visuomotor task.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Herseninfarct
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main outcome measure is the error in matching a template during VMP in the left
and right hand.
Secondary outcome
Mechanistic measures include the corticospinal excitability indexed by the size
of the motor evoked potentials (MEPs) produced by transcranial magnetic
stimulation (TMS), short-interval intracortical inhibition (SICI),
intracortical facilitation (ICF), ipsilateral silent period (iSP) and
contralateral facilitation (CLF).
Background summary
Afferent stimulation modulate motor output. Here we examine the possibility
that somatosensory stimulation (SS) can enhance motor learning and the transfer
to the non-exercising limb. The transfer effects are relevant because patients
with unilateral impairments (e.g. stroke patients, wrist fractures) can benefit
from training the intact side of the body but this cross-education effect (XED)
is relatively small, 10%. Based on evidence from the literature, we hypothesize
that SS enhances the direct and crossed effects of training. The main task
comprises a complex visuomotor task performed with the right hand of right hand
dominant healthy volunteers and SS is supplemented during the motor practice in
the form of gentle, percutaneous electrical stimulation.
Study objective
To determine if SS improves motor learning and transfer of a visuomotor task.
Study design
We will use acute (single session) and chronic (multiple sessions) visuomotor
practice (VMP) as an intervention and no-intervention as a control in a
pre-test post-test and a follow-up design.
Intervention
Non-invasive visuomotor training with the right wrist flexors and extensors
during a 25 minute session. Before, during or after VMP SS at 1Hz with an
intensity of two times perceptual threshold will be applied to either the
resting hand or the training hand.
Study burden and risks
Subjects report for the experiments to the Center for Human Movement Sciences.
In session one, subjects are familiarized with the experimental equipment and
procedures for about one and a half hour. Testing sessions last about 1.5 hour
and training sessions last about 30 minutes. Testing involves performance in
the visuomotor task and responses to TMS in the seated position. Training
sessions involve practice of the visuomotor task. TMS may cause slight
discomfort lasting less than a second on the scalp near the coil. It may also
cause some twitching of the muscles, the face and jaw, which may be unpleasant
and surprising but not painful. Peripheral muscle stimulation will be below
motor threshold, and can be more surprising than painful. It can cause some
momentary burning and tingling sensation. There are no known long-term risks of
peripheral muscle or magnetic brain stimulation.
Antonius Deusinglaan 1
Groningen 9700AD
NL
Antonius Deusinglaan 1
Groningen 9700AD
NL
Listed location countries
Age
Inclusion criteria
Age 18-30 years, female or male gender, right handed
Exclusion criteria
Fracture in the upper extremity over the past year, neurological disorders, pregnancy, medicine known to affect nerve conduction, Epilepsy, Pacemaker, metal in the brain/skull.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL46387.042.13 |
| OMON | NL-OMON29210 |