- The primary objective of this proposal is to assess the intraindividual reliability of PAS TMS, Theta-burst rTMS and ppTMS indices as measures of neural plasticity and cortical inhibition, by performing test-retest measurements separated by a…
ID
Source
Brief title
Condition
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The difference in the amplitude of the MEP of the APB muscle between baseline
TMS and after PAS, Theta-burst rTMS (TBS) or ppTMS as obtained during session 1
and session 2.
Secondary outcome
The neuropsychological tests scores.
Background summary
Long-term potentiation (LTP)-like plasticity and cortical inhibition can safely
be measured by means of motor evoked potentials (MEPs) from the Abductor
Pollicis Brevis (APB) thumb muscle as induced by Transcranial Magnetic
Stimulation (TMS) of the motor cortex.
Study objective
- The primary objective of this proposal is to assess the intraindividual
reliability of PAS TMS, Theta-burst rTMS and ppTMS indices as measures of
neural plasticity and cortical inhibition, by performing test-retest
measurements separated by a period of 2 weeks in healthy volunteers.
- The secondary objective is to explore relationships between indices of PAS
TMS, Theta-burst rTMS and ppTMS, and neuropsychological test scores in healthy
volunteers.
Study design
Observational test-retest design.
Study burden and risks
There are only minor risks associated with this study. TMS as used in this
protocol is considered safe and without elevated risk of seizures. However, we
will make use of a screening checklist for risk factors in order to avoid
potential TMS-related side effects. The participants will visit the Erasmus MC
twice, with at least 2 weeks in between the visits. During both sessions,
identical measurements will be made regarding electromyography (EMG), PAS TMS,
ppTMS and TBS. EMG measurements will be made from the right APB thumb muscle to
record MEPs by means of surface EMG, using disposable electrodes in
belly-tendon recording technique. For the PAS TMS measurements, 200 paired
stimuli will be administered at a frequency of 0.25 Hz with an interstimulus
interval (ISI) of 25 ms. For the ppTMS protocol, ISIs of 2, 3 and 15 ms will be
investigated at 3 levels of subthreshold stimulation, with 15 stimuli delivered
at random for each condition. The TBS protocol consists of bursts of three
pulses given at 50 Hz repeated every 200 ms. The stimulation intensity used in
this protocol is the 80% of the active motor threshold (AMT). Prior to the
first TMS session, there will be an intake in which two questionnaires will be
filled out and 6 neuropsychological tests will be performed. The total time
investment for testing of the participants will be approximately 6 hours (1x 2
hours and 2 x 2 hours). The participants will be reimbursed for travel costs
and they will receive ¤50,-.
dr. Molewaterplein 50
Rotterdam 3015GE
NL
dr. Molewaterplein 50
Rotterdam 3015GE
NL
Listed location countries
Age
Inclusion criteria
Subjects can be included if:
• They are in good health, based on medical history information, including current physical and mental condition
• They are medication free (females: except for hormonal contraceptives) and abstinent from the use of illicit drugs
• They are right-handed
• They are capable and willing to give written informed consent
• They are within the age range of 18-40 years
Exclusion criteria
Subjects will be excluded if:
• They are women who are pregnant or lactating
• They have a history of psychiatric illness and/or psychotherapeutic treatments
• They have a history of neurological illnesses
• They fulfil any of the exclusion criteria concerning the safety of TMS as assessed by means of the Transcranial magnetic stimulation Adult Safety Screen (TASS)
• They cannot understand the Dutch language sufficiently to understand the purposes and implications of the experiment
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL45245.078.13 |