The aim of this protocol is threefold.1. To investigate associations between alcohol dependence with demographic data, psychiatric problems (e.g., compulsive symptoms in Obsessive Compulsive disorder, and ADHD)2. To investigate familial transmission…
ID
Source
Brief title
Condition
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Addiction severity index (ASI), including demographic data
Alcohol use disorders identification test (AUDIT)
Cannabis use disorders identification test (CUDIT and additional items
CUDIT-Revised)
Fagerström test for Nicotine Dependence (FTND)
Gambling section of the EuropASI versie III (see ASI)
Compulsive Internet Use Scale (CIUS)
Eating Disorder Examination Questionnaire (EDE-Q)
Ethnicity
Mini-plus (modules A-P)
Adult ADHD Self-Report Scale (ASRS)
Hospital Anxiety and depression scale (HADS)
Family Interview for Genetic Studies (FIGS)
Secondary outcome
NA
Background summary
Alcohol dependence is a highly prevalent disorder with a large impact on
society. The disease has adverse physical, psychological, and social
consequences for patients and their relatives. Despite the high heritability,
little is known on the specific genetic risk factors
Study objective
The aim of this protocol is threefold.
1. To investigate associations between alcohol dependence with demographic
data, psychiatric problems (e.g., compulsive symptoms in Obsessive Compulsive
disorder, and ADHD)
2. To investigate familial transmission of alcohol dependence and
addiction-associated traits (e.g., gambling, nicotine dependence, compulsivity,
ADHD)
3. To identify novel genetic variants which influence alcohol dependence
Study design
40 patients and their relatives will be recruited at i) Parnassia Group ii) at
the Department of Psychiatry of the Academic Medical Centre, Amsterdam (AMC).
Study burden and risks
Burden is very small/absent. No risks involved
Meibergdreef 5
Amsterdam 1105 AZ
NL
Meibergdreef 5
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
1. Patients who have given informed consent to participate and who at the screening visit have met all the below stated inclusion criteria.;Diagnosed with alcohol dependence according to DSM-IV criteria
Age between 16-85 years
Caucasian ethnicity (i.e., defined as having at least three Caucasian grandparents)
A positive family history of alcohol dependence;2. Relatives who have given informed consent to participate and who at the screening visit have met all the below stated inclusion criteria.;Age between 16-85 years
Caucasian ethnicity (at least three Caucasian grandparents)
Exclusion criteria
Age below 16
Non-caucasian
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44352.018.13 |