To investigate whether the CVS patients show the muscle membrane disturbances, as the FMS patients do. That is, are there muscle conduction velocities disturbances in the CVS patients?
ID
Source
Brief title
Condition
- Muscle disorders
- Neuromuscular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Muscle conduction velocity
Secondary outcome
Nerve conduction velocity; the number of *tender points*; items from the
validated questionnaires.
Background summary
Chronic Fatigue Syndrome (CFS) is an often occurring incapacitating disorder
that has a great socioeconomic impact. CFS belongs to the group of medical
unexplained symptoms, which means that the causes and underlying mechanisms are
unknown. CFS has an overlapping in the symptoms with another unexplained
symptoms* disorder, the fibromyalgia syndrome (FMS). In FMS, we recently found
a disturbance in the muscle membrane function. In FMS, the muscle conduction
velocity is increased.
Study objective
To investigate whether the CVS patients show the muscle membrane disturbances,
as the FMS patients do. That is, are there muscle conduction velocities
disturbances in the CVS patients?
Study design
Observational study; three groups are being investigated: CFS-group, FMS-group
and a healthy control group.
Study burden and risks
The participants are visiting the institute twice; a total duration of the
visits is about four hours. The person undergoes a short physical examination
and non-invasive measurements are performed on the arm. The person completes
questionnaires. The burden is low and there are no risks associated with
participation.
Roessinghsbleekweg 33/B
Enschede 7522 AH
NL
Roessinghsbleekweg 33/B
Enschede 7522 AH
NL
Listed location countries
Age
Inclusion criteria
Group of Chronic Fatigue Syndrome (CVS-group): sufferers from chronic fatigue syndrome with the diagnosis confirmed by an interne physician.
Group of Fibromyalgia Syndrome (FMS-group): sufferers from (primary) fibromyalgia syndrome with the diagnosis confirmed by a rheumatologist.
Group of healthy people: healthy people that have explicitly no fatigue or pain.
Exclusion criteria
Having co-existent diseases such as diabetes, circulatory and respiratory diseases, hepatic, renal and adrenal diseases, polyneuropathy and myopathy, obesity. Using medication such as tranquilizers, anti-epileptics and morphine. Alcohol and drugs abuses. Using a wheelchair, orthoses for back, neck and dominant arm.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL46546.044.13 |