to investigate the relationship between the SDF-microscope focal setting necessary to obtain a sharp image of the sublingual microcirculation and the extent of edema formation, as indicated via cumulative fluid balance
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
patienten opgenomen op IC, na electieve chirurgie of acuut (dan niet gespecificeerd welke catagorie)
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
focal point of SDF microscope
recorded fluid balance at time of SDF imaging
Secondary outcome
admission category and electivity
clinical signs of edema formation
weight if measured
bio-impedance if measured
SOFA score
albumin
fluid therapy specified to type (0.9% NaCl, lactated ringer, gelofusin,
albumin, blood products, glucose)
Background summary
Edema, the accumulation of fluid in the interstitial space, is seen in a wide
range of disorders and is caused by either changes in oncotic- and/or
hydrostatic pressures, impaired fluid drainage by the lymphatics or excessive
leakage from the vasculature due to increased vascular permeability. Measuring
edema is not straightforward. The most used method is that of keeping record of
all fluids going in and out of the patient, the fluid balance. A positive net
fluid balance indicates edema formation, but this is hardly a precise method.
We hypothesize that the accumulation of interstitial fluid is directly related
to the focal setting needed to acquire a sharp image with the SDF microscope
used for imaging the sublingual microcirculation.
Study objective
to investigate the relationship between the SDF-microscope focal setting
necessary to obtain a sharp image of the sublingual microcirculation and the
extent of edema formation, as indicated via cumulative fluid balance
Study design
observational
Study burden and risks
no benefit for the patient, very minimal burden, with no additional risks
de Boelelaan 1117
Amsterdam 1081 HV
NL
de Boelelaan 1117
Amsterdam 1081 HV
NL
Listed location countries
Age
Inclusion criteria
age: 18 y and older
admittance to the intensive care unit
elective surgery OR
medical or surgical patients with emergency admittance and expected intubation period over 24 hours
at least one sharp SDF recording (per timepoint),
Exclusion criteria
influences that would severely reduce the accuracy of the recorded fluid balance (i.e. internal or external bleeding, incomplete fluid registration)
intra-oral bleeding
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47067.029.13 |