To study AC changes of the RNFL in neuro-ophthalmic diseases.
ID
Source
Brief title
Condition
- Eye disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
AC (Spectralis OCT).
Secondary outcome
Visual field, retinal layers thickness.
Background summary
Spectral Domain * Optical Coherence Tomography (SD-OCT) provides images of
structures such as the retinal nerve fiber layer (RNFL). However, conventional
SD-OCT diagnostics of glaucoma, a condition affecting the RNFL, is relatively
susceptible to artefacts. Therefore, another approach, less prone to artefacts,
was developed, i.e. by means of the attenuation coefficient (AC). The AC is a
quantitative, objective measure for the scattering and absorption properties of
tissue. Recently, we have shown that the AC of the RNFL decreases with the
severity of glaucoma. It is expected that the AC may also serve for better
detection of RNFL damage caused by various other diseases.
Study objective
To study AC changes of the RNFL in neuro-ophthalmic diseases.
Study design
Prospective, observational, well-defined case series.
Study burden and risks
Risks are negligible, inconvenience is minimal. Participants do not benefit.
Exclusively study-related visits: ON or NAION, 2; pituitary tumor, 5. A study
visit lasts approximately two hours.
Schiedamse Vest 180
Rotterdam 3011 BH
NL
Schiedamse Vest 180
Rotterdam 3011 BH
NL
Listed location countries
Age
Inclusion criteria
age * 18 years
(optic neuritis OR
pituitary tumor OR
NAION)
Exclusion criteria
- Refractive error outside -10.0 to +5.0 diopter range.
- Cataract surgery in previous 12 months.
- Previous refractive or vitreoretinal surgery.
- Previous keratoplastic surgery.
- Evidence of diabetic retinopathy, diabetic macular edema or other vitreo-retinal disease.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47998.078.14 |