The aim of this study is to determine phosphorus metabolite levels in the brain of healthy elderly, who are age and gender matched to the AD patients that participate in the nutritional intervention (MRS AD) study, to identify disease specific…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
gezonde veroudering
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Outcome measures are relative metabolite levels of the phosphomonoesters
phosphocholine and phosphoethanolamine, and of the phosphodiesters
glycerophosphocholine and glycerophosphoethanolamine to total phosphorus
signal, the ratio of phosphomonoesters to phosphodiesters, and relative
metabolite levels of alpha, beta and gamma adenosinetriphosphate,
phosphocreatine, inorganic phosphate and nicotinamide adenine dinucleotide to
total phosphorus signal.
Secondary outcome
Blood parameters: Fatty acid profile in erythrocyte membrane, fatty acid
profile in plasma, Choline, Homocysteine, Vitamin E, Uridine, and optionally,
plasma phospholipids.
Background summary
Synaptic loss is a hallmark feature of Alzheimer*s disease (AD) and
abnormalities in the lipid composition of neural membranes have been identified
in the brains of AD patients. In addition, resting energy metabolism in the
retrosplenial cortex (RSC) as measured by FDG-PET is consistently found to be
reduced in AD. Phospholipid metabolism, important for the formation of new and
maintenance of existing synapses, and energy metabolism, crucial to brain
functioning, can be assessed in vivo with phosphorus magnetic resonance
spectroscopy (31P-MRS). Presently, only a very limited number of 31P-MRS
studies in AD have been published, with inconclusive results, due to the use of
different control groups and different brain regions being investigated. This
makes it almost impossible to discriminate between changes related to AD and
normal aging. In addition, spectral resolution in these studies was relatively
poor.
In this study we will investigate phospholipid and energy metabolism in
multiple brain areas in healthy elderly controls, as an add on to a running
nutritional intervention study in AD patients (MRS AD study). Together, these
studies are unique in that they aim to separate the individual components of
phosphomono- and diester resonances. In addition, we investigate several brain
areas simultaneously, by performing 3D whole brain measurements. The proposed
study would additionally be beneficial for the interpretation of the outcomes
of the MRS AD study.
Study objective
The aim of this study is to determine phosphorus metabolite levels in the brain
of healthy elderly, who are age and gender matched to the AD patients that
participate in the nutritional intervention (MRS AD) study, to identify disease
specific alterations.
Study design
This is a one-visit magnetic resonance imaging and spectroscopy (MRI/MRS)
study. Subjects who appear to fulfill the eligibility criteria are informed
about the study. After having signed informed consent a one-hour MRI/MRS
measurement is performed. In addition, one blood sample is taken and subject
characteristics are collected.
Study burden and risks
This is a one-visit magnetic resonance imaging and spectroscopy (MRI/MRS) study
including 1 blood sample (3 vials). There are minimal risks involved in
participation. The burden of participation is one MRI (lasting one hour),
filling out a food diary and giving 1 blood sample.
Reinier Postlaan 4
Nijmegen 6500 HB
NL
Reinier Postlaan 4
Nijmegen 6500 HB
NL
Listed location countries
Age
Inclusion criteria
aged 60 years or older
Exclusion criteria
Significant neurological or psychiatric disease
MRI contra-indications
Use within two months prior to visit of:
- omega-3 fatty acid containing supplements
- oily fish (when consumed more than twice a week)
Use within one month prior to visit of:
- vitamins B, C and/ or E > 200% RDA
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL48455.091.14 |