Identification of protein profile differences between laryngeal cancer of young and elderly patients. Secondary objective is to identify differences between protein interaction network in cancer and healthy tissue in young and elderly laryngeal…
ID
Source
Brief title
Condition
- Respiratory and mediastinal neoplasms malignant and unspecified
- Respiratory tract neoplasms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Identification of protein profile differences between laryngeal cancers of
young and elderly patients, by comparing differential expression of proteins in
cancer and healthy tissue of the same patients, determined by Liquid
Chromatography Tandem Mass Spectometry (LC-MS/MS) using the Orbitrap/qTOF mass
analyzer.
Secondary outcome
Identification of differences between protein interaction network in cancer and
healthy tissue between elderly and young laryngeal cancer patients, determined
by Liquid Chromatography Tandem Mass Spectometry (LC-MS/MS) using the
Orbitrap/qTOF mass analyzer.
Background summary
Over the past years head and neck cancer (HNC) incidence is increased in the
elderly population. Aetiology of HNC in young and elderly patients seems
different. Excessive smoking and alcohol consumption are less often registered
in elderly HNC patients. It is very likely that accumulation of spontaneous
genetic mutations and an impaired immune system play an important role in
developing cancer in elderly. Based on these facts, it is hypothesized that
there are different molecular mechanisms in the development of HNC in young and
in elderly patients. Since prognosis is also determined by molecular
characteristics of the tumor, this difference could be valuable in decision
making on treatment.
Study objective
Identification of protein profile differences between laryngeal cancer of young
and elderly patients. Secondary objective is to identify differences between
protein interaction network in cancer and healthy tissue in young and elderly
laryngeal cancer patients.
Study design
Pilot study in a prospective observational cohort.
Study burden and risks
During the diagnostic procedure, one additional biopsy of the tumour will be
taken for this study. Also, a biopsy of the healthy mucosa from the
contralateral side of the larynx will be performed. (Temporary) dysfonia,
bleeding and infection could be possible risks of a biopsy, but are extremely
rare. Age criteria in both patient groups are chosen to make a clear
distinction between young and elderly patients. Included patients dot not
benefit from the study.
Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
Newly diagnosed squamous cell laryngeal cancer;
Malignancy limited to one side of the larynx;
Age <65 years (n=10) or age >=75 years (n=10);
Written informed consent;
WHO performance status 0-2.
Exclusion criteria
Age >= 65 years and < 75 years;
Previous treatment of laryngeal cancer;
Previous radiation therapy in head and neck area;
Diagnostig laryngoscopy in emergency situation.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL50497.042.14 |