To examine the acute impact of tea ingestion on forearm resistance artery endothelial function in middle-aged subjects
ID
Source
Brief title
Condition
- Cardiac disorders, signs and symptoms NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Forearm resistance artery blood flow (measured using venous occlusion
plethysmography) in response to incremental doses of acetylcholine
(endothelium-dependent dilator; primary parameter), sodium nitroprusside
(endothelium-independent dilator; secondary parameter) and L-NMMA (nitric oxide
synthase blocker; secondary parameter).
Secondary outcome
Blood pressure
Background summary
Lifestyle-interventions, such as diet, can importantly impact cardiovascular
health. For example, epidemiological studies indicate that regular consumption
of black tea reduces the risk of cardiovascular diseases. Indeed, tea is
demonstrated to decrease systolic and diastolic blood pressure, which may
possibly be mediated through its effects on the endothelial function of
resistance arteries. Whilst is well established that tea consumption can
improves endothelial function in conduit arteries, as measured by the
flow-mediated dilation, little is known about the potential impact of tea
ingestion on endothelial function of resistance vessels.
Study objective
To examine the acute impact of tea ingestion on forearm resistance artery
endothelial function in middle-aged subjects
Study design
Cross-over within-subject intervention studie
Intervention
Tea ingestion
Study burden and risks
Tea is not associated with serious health risks. Actually, regular tea
ingestion is related to protection against cardiovascular disease/risk.
Although our primary outcome measures relates to non-invasive measurement of
forearm blood flow, this procedure involves cannulation of the brachial artery
and local infusion of vasoactive substances. This latter procedure, however, is
frequently used at Radboudumc over the past 20 years, whilst the Department of
Physiology has extensive experience using this model. A potential risk of this
procedure is the occurrence of a hematoma (5%), induced during the procedure.
This hematoma will resolve within 2 weeks, whilst the subjects will not have
any practical limitation during this timeframe.
Olivier van Noortlaan 120
Vlaardingen 3133 AT
NL
Olivier van Noortlaan 120
Vlaardingen 3133 AT
NL
Listed location countries
Age
Inclusion criteria
- Males and post-menopausal (> 1 years) females
- Aged >45 and < 75 years
- Body mass index (BMI) of *18.0 and *35.0 kg/m2
Exclusion criteria
- Regular performance of strenuous exercise/sport of > 2 hours per week
- Current smoker or has stopped smoking less than 6 months before start of study
- Self reported alcohol intake of >21 units/week)
- Established cardiovascular disease
- Diabetes mellitus
- Blood pressure > 160/100 mmHg
- Subjects taking any medication that might affect endothelial function (e.g. but not limited to beta-blockers, ACE-inhibitors, statins, anti-coagulants, anti-depressants, hormone replacement therapy) will be excluded from the study. Subjects who are on stable medication for which there is no indication of an effect on endothelial function, will be allowed to participate.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL50113.091.14 |