Collection of skin tissue and blood samples from patients with mild to moderate psoriasis for further research in a humanized mouse model.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Donatie weefsel voor proefdieronderzoek (gehumaniseerd muismodel) voor psoriasis
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Not applicable
Secondary outcome
Not applicable
Background summary
Psoriasis is a highly prevalent disease (2-3% worldwide) with great impact on
the quality of life of patients. Current treatments are suboptimal. The
development of novel therapeutics requires validation in an animal model. Since
the skin of most test animals differs significantly from humans, a humanized
mouse model for psoriasis can be applied to evaluate the efficacy of compounds
to treat psoriasis vulgaris.
Study objective
Collection of skin tissue and blood samples from patients with mild to moderate
psoriasis for further research in a humanized mouse model.
Study design
Single-center study in the Netherlands
Intervention
Collection of blood samples (40 mL)
Collection of skin tissue (4 biopsies)
Study burden and risks
- Blood samples will be collected via vena-puncture with possible risks of
slight hemorrhages and bruising at the puncture site. Furthermore, the subject
may faint or experience dizziness.
- Skin tissue will be collected via a skin biopsy procedure with the possible
risks of mild pain, bleeding from the biopsy site, local reaction to the
anesthetic and scar tissue formation.
The risks are considered to be very low.
There is no direct benefit for the subjects participating in the study as the
skin and blood samples will be collected for further use in animal studies,
investigating new treatments for psoriasis vulgaris.
Utrechtseweg 48
Zeist 3704 HE
NL
Utrechtseweg 48
Zeist 3704 HE
NL
Listed location countries
Age
Inclusion criteria
- Written Informed Consent obtained
- Suffering of mild to moderate psoriasis vulgaris
- PASI score of 18 or less and a minimum of BSA of 3% at Visit 1
Exclusion criteria
- Suffering from extensive psoriasis or having had nonplaque or drug-induced forms of psoriasis
- Undergoing light therapy or any systemic therapy
- A recent serious infection or a history of chronic or recurrent infectious disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL50948.028.14 |