To compare the neurotransmitter networks of patients with localisation-related epilepsy patients to those of healthy subjects; To explore the relationship between neurotransmitter, functional and structural network properties, and relate these to…
ID
Source
Brief title
Condition
- Seizures (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameters are the neurotransmitter network properties of
MRI-negative localization-related epilepsy patients compared to those of
healthy subjects.
Secondary outcome
Secondary study parameters are functional and structural network properties and
the relation between these and the neurotransmitter network properties of
MRI-negative localisation-related epilepsy patients.
Background summary
A large portion of patients with intractable epilepsy does not become
completely seizure free after resection of the epileptic focus in epilepsy.
This ineffectiveness might be due to the fact that epilepsy is not necessarily
a purely focal disease, but rather is associated with widespread network
alterations in the brain, for which deficient functional and structural
networks have previously been shown in epilepsy patients. However, these
networks do not provide direct information on the defective neurons or the
linked neurotransmitter disbalance. We propose the novel application of graph
theoretical analysis in magnetic resonance spectroscopic imaging, to provide
insight into the neurotransmitter network dysfunction in MRI*negative epilepsy.
This will be of great value to eventually better understand the neuronal
network characteristics of epilepsy and potentially the underlying mechanism of
surgical failure in epilepsy.
Study objective
To compare the neurotransmitter networks of patients with localisation-related
epilepsy patients to those of healthy subjects; To explore the relationship
between neurotransmitter, functional and structural network properties, and
relate these to clinical characteristics.
Study design
This is an observational study comparing epilepsy patients with healthy
subjects. MRI measures of MRI-negative localization-related epilepsy patients
will be compared to those of healthy subjects, matched for age and gender. Each
subject will undergo MRI measurements at one time point.
Study burden and risks
The subjects will undergo one MR scanning session (about 1 hour in duration)
at a 7T MRI scanner. The patient group might benefit from this scan, because
occasionally structural lesions can be found at 7T that were not found at the
clinical scans at 3T, and thereby improving the possibilities for epilepsy
surgery. However, we argue that this has a small chance. The risks for the
subjects participating in this study are minimal. A small amount of people may
experience vertigo or nausea while entering the scanner, but not during the
scan itself. Also a smaller amount of people may experience a metallic taste in
their mouth during the scan.
P. Debyelaan 25
Maastricht 6202 AZ
NL
P. Debyelaan 25
Maastricht 6202 AZ
NL
Listed location countries
Age
Inclusion criteria
General:
Subjects must be older than 18 years and able to give informed consent. ;Epilepsy patients:
- Diagnosed with cryptogenic localization-related epilepsy with an epileptic focus in the frontal or temporal lobe (using EEG)
- Seizure frequency below 13/year.
- No changes in anti-epileptic drugs (medication or dose) in the last 6 months.
Exclusion criteria
General:
- MRI visible lesions, as seen on the clinical 3T scans
- All absolute or relative contraindications for MR scanning.
- A medical history with cerebral diseases (other than epilepsy), vascular problems, diabetes mellitus, hypertension and/or cerebral surgery.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL50613.068.14 |