Objective:The aim of this project is to apply motor-cognitive-mental elements together for psychiatric diagnosis, treatment, and prevention. We will examine and quantify the diagnostic value of motor-cognitive-mental elements in predicting (a)…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints:
MSD-ESM makes it possible to collect synchronised momentary measures of motor
function, cognitive function and mental experience.
Nature and extent of the burden and risks associated with participation,
benefit and group relatedness:
The risk associated with the study is minimal. Subjects will be asked to invest
a total of 18 days. This figure will be the same for all subjects as the study
consists of a single group.
Secondary outcome
At baseline, and at 1 month and 3 months post-baseline
• Quality of life
• Prevalence and incidence of motor, cognitive, and mental signs and symptoms
Background summary
Page 10 of research protocol
Rationale:
The main function of diagnosis in medicine is to provide accurate information
to predict treatment needs (management) and treatment response (prognosis).
However, in psychiatry the predictive value of (DSM/ICD) *mental* signs and
symptoms is limited. Interestingly, alterations in motor and cognitive function
represent more accurate predictors, likely because they are indicators of
neurodevelopmental liability, and may dramatically enhance diagnostic
usefulness. The critical question is: is it feasible and practicable to add
areas of motor and cognitive function to standard diagnostic function in mental
health care?
Keywords: motor, cognition, mental, diagnosis, personalised
Study objective
Objective:
The aim of this project is to apply motor-cognitive-mental elements together
for psychiatric diagnosis, treatment, and prevention.
We will examine and quantify the diagnostic value of motor-cognitive-mental
elements in predicting (a) treatment needs, and (b) 3-month treatment response.
It is hypothesized that the diagnostic value of motor-cognitive-mental elements
will yield early predictive parameters of treatment needs and treatment
response, which display diagnostic value over and above traditional diagnostic
formulations in psychiatry, and represent a highly useful personal diagnostic
tool, complementing the standardised criteria in DSM/ICD.
Study design
Study design:
Ambulatory assessment methodology, i.e. in the flow of daily life, will be used
to collect intensive time-sampling data of mutually impacting motor, cognitive
and mental alterations. I will use Motor Sensor Devices (MSD) in combination
with Experience Sampling Methodology (ESM) (together: MSD-ESM). MSD-ESM makes
it possible to collect synchronised momentary measures of motor function,
cognitive function, and mental experience. Data will be collected in the flow
of daily life over 3 periods of 6 days at baseline, and at 1 month and 3 months
post-baseline.
Study burden and risks
The risk associated with the study is minimal. Subjects will be asked to invest
a total of 18 days. This figure will be the same for all subjects as the study
consists of a single group.
Utrechtseweg 266
Amersfoort 3818 EW
NL
Utrechtseweg 266
Amersfoort 3818 EW
NL
Listed location countries
Age
Inclusion criteria
Minimum age of 18 years, recent-onset affective/psychotic psychopathology, and sufficient command of the Dutch language.
Is mentally incompetent (wilsbekwaam) according the algorithm from the Royal Dutch Medical Association (KNMG) , i.e. the patient is able to make choices, understands medical information, can apply this to his/her own situation, and whether he/she is able to logically consider the choice. (Mental incompetence is a legally defined status - there is no straightforward relation between mental incompetence and the underlying diagnosis)
Exclusion criteria
A history of neurological disorder impacting motor/cognitive function.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL49253.068.14 |