The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs) on psoriasis skin biopsy gene expression in vitro.
ID
Source
Brief title
Condition
- Autoimmune disorders
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
A decrease in skin mediator RNA levels.
Secondary outcome
N/A
Background summary
Psoriasis is an auto-immune skin disease in which pro-inflammatory protein
mediators, released by skin cells and infiltrating cells, cause an abnormal
cell division and differentiation. It may be possible to treat psoriasis using
drugs aimed at preventing the synthesis of such mediators.
Study objective
The specific aim of the project is to determine the efficacy of Spherical
Nucleic Acids (SNAs) on psoriasis skin biopsy gene expression in vitro.
Study design
The 3mm diameter lesional skin biopsies will be treated with the test
preparations in vitro and epidermal RNA isolated. Analysis of the RNA will
allow the company to see if their preparation down-regulates expression of
pro-inflammatory genes involved in the pathogenesis of psoriasis.
Study burden and risks
The health risks associated with this research are small, possibly slight scar
formation at biopsy sites. The healed sites may be psoriasis free.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
Patients with psoriasis vulgaris, moderate to sever.
Exclusion criteria
-Volunteers undergoing light therapy or taking systemic drugs such as methotrexate or cyclosporine A.
-Volunteers using local topical corticosteroids.
-Volunteers who develop psoriasis at wound sites (Köbner phenomenon).
-Volunteers with atopic dermatitis/eczematous skin conditions.
-Pregnancy
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL50899.098.14 |