We aim to investigate whether reinstatement of cortical representations are necessary for successful memory retrieval.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
not applicable
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Memory performance on the orientation matching task will be addressed as a
function of stimulation condition: we expect that TMS to the hemisphere
contralateral to the location of the retrieved stimulus impairs memory
performance (as measured by adjustment error in degrees) compared to no
contralateral TMS, while performance between no TMS and TMS ipsilateral to
recall site does not differ.
Secondary outcome
Not applicable.
Background summary
The cortical reinstatement hypothesis posits that during retrieval of a
stimulus, cortical regions that were involved in initial encoding of that
stimulus reinstate their stimulus representation. In previous work, we have
provided evidence for this hypothesis even at the lowest level of the visual
hierarchy. However, this work was correlational in nature, and therefore cannot
answer the question whether reinstatement is necessary for memory retrieval.
Here we combine online TMS and a cued recall paradigm to test a possible causal
role of mnemonic reinstatement for retrieval.
Study objective
We aim to investigate whether reinstatement of cortical representations are
necessary for successful memory retrieval.
Study design
Experimental within-subject (cross-over) design with healthy volunteers.
Intervention
TMS will be applied to the early visual cortex while participants recall
previously learnt associations. We expect TMS to impair associative recall,
providing causal evidence for the necessity of cortical reinstatement for
memory retrieval.
Study burden and risks
For the assessment of risks and burden associated with transcranial brain
stimulation in this study please refer to paragraph 5.2 of the approved
Standard Operating Procedure for Non-Invasive Brain Stimulation (v. 2.1., CMO
No. 2013/245) at the Donders Institute for Brain, Cognition and Behaviour.
Kapittelweg 29
Nijmegen 6525EN
NL
Kapittelweg 29
Nijmegen 6525EN
NL
Listed location countries
Age
Inclusion criteria
Please refer to 'Donders Institute Standard Operating Procedure for Non-Invasive Brain Stimulation' - Document number SOP 2013/245 - Section 6.2, 'Screening' and Section 6.3, 'Exclusion Criteria'.
Exclusion criteria
Please refer to 'Donders Institute Standard Operating Procedure for Non-Invasive Brain Stimulation' - Document number SOP 2013/245 - Section 6.2, 'Screening' and Section 6.3, 'Exclusion Criteria'.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL50328.091.14 |