To investigate the underpinnings of ADHD and its persistence into adulthood: Through studying genetic factors, in combination with genomic, microbiome, cell-based, neuroimaging, neuropsychological and psychiatric assessment we aim to gain more…
ID
Source
Brief title
Condition
- Neurological disorders congenital
- Cognitive and attention disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Differences in genetic profile, brain-anatomy and brain-function between ADHD
probands, their family members and healthy controls.
Secondary outcome
n.a.
Background summary
ADHD is a highly prevalent, chronic psychiatric disorder with childhood onset,
that impairs multiple areas of life. Heritability of the disorder is estimated
to be between 70 and 80%, though, the genes and genetic pathways involved are
still largely unknown. Genetic factors are thought to be of stronger influence
in ADHD that persists into adulthood, compared to ADHD that remits. Therefore,
in addition to being the most relevant group to study in terms of disease
burden, patients suffering from persistent ADHD are an excellent group to study
the genomics of ADHD.
Study objective
To investigate the underpinnings of ADHD and its persistence into adulthood:
Through studying genetic factors, in combination with genomic, microbiome,
cell-based, neuroimaging, neuropsychological and psychiatric assessment we aim
to gain more insight into the aetiology of ADHD, so that it will be possible to
distinguish persistent forms of ADHD from childhood ADHD. As a result we hope
to gain deeper insights into the mechanisms underlying ADHD, which could lead
to improved and individualized therapeutic and prophylactic treatment.
Study design
Observational (longitudinal) case-control study. Participants will be invited
for two visits. During the first visit, psychiatric assessment (DIVA and SCID
interview) as well as blood (50ml) (or saliva, 2ml) extraction takes place.
During the second visit, neuropsychological testing and MRI scanning takes
place. Participants will be asked to repeatedly complete questionnaires via a
website.
Study burden and risks
The risk of participation in the study is negligible. A small risk for the MRI
measurement exists, though we try to reduce this risk as much as possible by
only inviting participants that can safely undergo MRI examination. The
occurrence of an incidental finding in the imaging and genetic parts of the
study could possibly have social consequences for the participant. No direct
benefit for participants exists, though participation helps gaining insight in
the aetiology of persistent ADHD and with that, the development of novel
therapies.
Geert Grooteplein 10
Nijmegen 6525 GA
NL
Geert Grooteplein 10
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
>/= 18 years old
ADHD diagnosis by psychiatrist
IQ > 80
caucasian descent
able to undergo MRI examination
Exclusion criteria
< 18 years
> 60 years
current depression
current use of antipsychotic drugs
current use of an SSRI
addiction in the last 6 months
any metal part in the body
non-caucasian descent
neurological disorders in present or past
(suspection of) pregnancy
other significant diseases;Additional to healthy control participants:
direct family members that suffer from psychiatric or neurological disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47721.091.14 |