To assess the potential of a short neuropsychological test measuring attentional variability and vigilance preoperatively in predicting postoperative delirium among elderly non-dementia patients undergoing elective surgery.
ID
Source
Brief title
Condition
- Encephalopathies
- Deliria (incl confusion)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Mean preoperative intra-individual reaction time variability among
postoperative delirious and non-delirious patients.
Secondary outcome
- Mean preoperative individual accuracy of response among postoperative
delirious and non-delirious patients.
- Sensitivity and specificity of a combined index of preoperative
intra-individual reaction time variability and accuracy of response in
predicting postoperative delirium.
Background summary
Delirium is a common complication that occurs in various medical conditions.
Validated models predicting delirium in individual patients are scarce and
existing models tend to focus exclusively on demographic characteristics and
comorbid conditions. Previous research has suggested that impairment of
attentional function might serve as an early and specific individual predictor
of incident delirium. Utilization of a test of attentional function in a
clinically easy-to-use way could potentially yield a pathophysiological monitor
to identify individual patients at risk of evolving delirium and target future
prophylactic treatment.
Study objective
To assess the potential of a short neuropsychological test measuring
attentional variability and vigilance preoperatively in predicting
postoperative delirium among elderly non-dementia patients undergoing elective
surgery.
Study design
An observational prospective cohort study.
Study burden and risks
There are no risks associated with participation in this study. The burden of
participation consists of a small test battery during anaesthetic preassessment
at the outpatient clinic, taking approximately an hour. Subjects will have no
direct benefit from participating in the study.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
* Age *70 years
* Elective surgery
Exclusion criteria
* Preceding diagnosis of dementia or Clinical Dementia Rating (CDR) *1
* Language barrier enough to hamper informed consent and testinstructions
* Serious functional disability of the dominant hand (e.g. palsy, amputation, arthrodesis)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47720.018.14 |