To investigate the effect of androgeninsufficiency on sexual function in women with POI. Also, to map the sexual dysfunction in different domains and compare this data to medically healthy women with sexal problems and medically healthy women…
ID
Source
Brief title
Condition
- Other condition
- Endocrine disorders of gonadal function
- Ovarian and fallopian tube disorders
Synonym
Health condition
seksuele functie- en fertiliteitsstoornissen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Hormone determinations:
- FSH
- 17-ß estradiol
- total testosterone
- SHBG
- Free testosterone (calculated with Free Androgen Index (FAI): [total
testosterone] / [SHBG] x 100)
- DHEA
2. Genital response measured as VPA during:
- self-induced erotic fantasy
- watching sexual stimuli (erotic film)
- at baseline
3. Subjective genital response determined by questions about:
- overall feeling of sexual arousal
- strongest feeling of sexual arousal
- strongest genital sensation
- amount of vaginal lubrication
4. Implicit associations respective to sexual stimuli by measuring reaction
times
Secondary outcome
Questionnaires: FSFI, FSDS-R, MMQ
Background summary
Little is known about the influence of androgens on female sexual function and
about sexual dysfunction in women with POI. Androgen levels below the normal
range and sexual dysfunction appear to be related in postmenopausal women and
women with HSDD. Testosterone suppletion is an effective treatment in these
groups.
Study objective
To investigate the effect of androgeninsufficiency on sexual function in women
with POI. Also, to map the sexual dysfunction in different domains and compare
this data to medically healthy women with sexal problems and medically healthy
women without sexual problems.
Study design
A cross-sectional study
Study burden and risks
We do not expect any risks. The burden consist of filling in three
questionnaires (which contain intimate questions), two computer tasks, blood
donation and a psychophysiological experiment.
If the questionnaires and/or the psychophysiological test are mentally taxing
for the participant, help will be offered.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
- POI patient
- Being treated for POI
- Aged 18 - 39
- Understanding of Dutch language
- Able and willing to provide informed consent
- In a relationship (>3 months)
- Control groups should be using one of the following birth control methods: the second, third or fourth generation pill or Mirena intra uterine device
Exclusion criteria
- Oophorectomy or radiation of the ovaries
- Androgen therapy during the six months prior to study start
- Lactation and/or pregnancy in the six months prior to study start
- Subjects experiencing relational discord as indicated by a score of >= 20 on the MMQ-M
- Other birth-control methods than described at inclusion criteria or no birth-control
- Chronic disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47715.018.14 |