The objective of this study is to investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as identified in epigenome-wide…
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To investigate whether the differences in DNA methylation between individuals
who were exposed in utero to the Dutch Hungerwinter and their non-exposed,
siblings as identified in epigenome-wide studies are transmitted to a second
generation.
Secondary outcome
Secondary endpoint of this study is the measurement of genetic variation. DNA
methylation differences within and between generations may be driven or
confounded by genetic variation.
Background summary
There is an increasing concern that adverse circumstances during gestation not
only influence health of the prenatally exposed individual but will also of
their offspring. Such intergenerational effects may explain the current
epidemic in non-commutable diseases (NCDs) including obesity and type 2
diabetes. Although still controversial, epigenetic mechanisms are frequently
invoked as an explanation. Few human studies are suitable to address this
hypothesis in humans. Studies on historical famines, in particular the Dutch
Hunger Winter, may be among the best-suited possibilities.
Study objective
The objective of this study is to investigate whether the differences in DNA
methylation between individuals who were exposed in utero to the Dutch
Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as
identified in epigenome-wide studies - are transmitted to a second generation
(F2).
Study design
A family based follow-up study with in utero (F1) and indirect (F2) to the
Dutch Hungerwinter exposed subjects compared with non-exposed siblings (F1,
F2).
Study burden and risks
The risks to participate in this study are minimal.
Einthovenweg 20
Leiden 2333ZC
NL
Einthovenweg 20
Leiden 2333ZC
NL
Listed location countries
Age
Inclusion criteria
Preferably families will be included where the exposed F1 (F1e) and the non-exposed sibling (F1c) together with two of their offspring (F2e, F2c), i.e. four subjects in one family (F1e, F1c, F2e, F2c) agree to participate. However, incomplete families will be included as well.
Exclusion criteria
We will exclude control individuals if they were born between November 1944 and March 1946 and lived in a town that was known to be affected by the Dutch Famine.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47531.058.14 |