Identification of the molecular and cellular muscular mechanisms associated with aging in rotator cuff muscles with radiological quantification and clinical data.
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Growth capacity, Cell fusion, microarray (RNA)
Secondary outcome
MRI/CT quantification (pathology, fatty infiltration, muscle atrophy), Clinical
scores (Constant score, range of motion, muscle strength, VAS, DASH and WORC).
Background summary
The ageing of skeletal muscles is associated with a progressive loss of
cellular functions leading to an increasing muscle weakness. In the elderly,
muscles may loose strength and become atrophic. Since shoulder mobility is
primarily supported by the rotator cuff muscles, an aging-associated decline in
muscle function could play a major role in the development and/or in the
persistence of complaints of rotator cuff pathology. So far very little is
known about aging-associated cellular and molecular defects in the rotator
cuff.
Study objective
Identification of the molecular and cellular muscular mechanisms associated
with aging in rotator cuff muscles with radiological quantification and
clinical data.
Study design
Observational, cross sectional study.
Study burden and risks
Because all interventions we will apply are standard treatment of patients with
symptomatic massive rotator cuff tear, risks and possible burdens are the same
as compared to the standard clinical situation. Only when the new MRI sequence
(Dixon scan) is available, it will cost extra time for the patient. Muscle
tissue samples will be within the operation area. No additional risk or burden
is involved. No physiological discomfort during test administration is to be
expected. The questionnaires, biomechanical measurements will cost extra time
for the patient. Appointments are scheduled the same day as the appointments
made at the outpatient clinic for usual healthcare.
Albinusdreef 2
Leiden 2333 ZA
NL
Albinusdreef 2
Leiden 2333 ZA
NL
Listed location countries
Age
Inclusion criteria
Patients undergoing MRI/CT evaluation of the shoulder. For biopsies collection, MRI/CT proven shoulder pathology for which shoulder surgery is needed. These will include, but not be limited to:
- Shoulder instability (primary)
- Rotator cuff tearing
- Osteoarthritis
- Fractures
Exclusion criteria
- Age < 18 and > 80 years
- No informed consent
- Comorbidity: neurological disorders (stroke, M. Parkinson, dementia, muscle disease), rheumatoid arthritis, polymyalgia rheumatic, heart failure, COPD (Gold III-IV), chronic pain syndrome (fibromyalgia, complex regional pain syndrome etc)
- Metabolic diseases (e.g. insuline dependent DM)
- Cancer
- Medication: immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc))
- Limited access to obtain muscle biopsies due to surgical exposure.
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44516.058.13 |