Primary Objective: To evaluate whether exercise leads to an increase total reflux time. Secondary Objective(s): - To evaluate whether the increase in reflux correlates with: exercise intensity, failure of the LES to act as an effective barrier,…
ID
Source
Brief title
Condition
- Gastrointestinal motility and defaecation conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Total reflux time (% of time with esophageal pH<4)
Secondary outcome
- Total number of reflux episodes (acid and non-acid)
- LES function
- Intra-abdominal pressure
- Esophageal motility
- Frequency of TLESRs
- Frequency of TLESRs with reflux
- Frequency of non-TLESR reflux events
- Reflux symptoms (heartburn, regurgitation)
Background summary
Gastroesophageal reflux disease (GERD) is caused by the reflux of gastric
contents into the esophagus. GERD symptoms tend to be common among athletes,
with epidemiological data indicating that upper gastrointestinal symptoms occur
in up to 58% of surveyed athletes. Previous studies have shown that strenuous
exercise can induce excessive reflux, both in patients with GERD and in
asymptomatic healthy subjects, and that this mainly occurs during vigorous
exercise, suggesting that strenuous physical activity can be a risk factor for
GERD.
Currently, the mechanisms underlying excess reflux during exercise are unclear.
Some studies suggest that reflux can influence athletic performance due to
symptoms such as heartburn or regurgitation, but also due to an increased
airway resistance due to acid reflux, which could compromise maximal
competitive performance.
Study objective
Primary Objective: To evaluate whether exercise leads to an increase total
reflux time.
Secondary Objective(s):
- To evaluate whether the increase in reflux correlates with: exercise
intensity, failure of the LES to act as an effective barrier, increased
intra-abdominal pressure and reflux symptoms.
- To evaluate the effect of high-intensity exercise on esophageal motility, and
more specifically the effect on peristaltic contractions.
- To evaluate the frequency of TLESRs during exercise.
Study design
A prospective observational design. Patients will run on a treadmill at
predetermined rates and for different durations after placement of both an HRM
catheter and a pH-impedance catheter.
Study burden and risks
There are no risks involved in the placement of the catheters for esophageal
pH-impedance and pressure monitoring. The investigative procedure may induce
some discomfort in the nose and throat. Participants will be compensated
financially for participation in the study.
Meibergdreef 9
Amsterdam-Zuidoost 1105AZ
NL
Meibergdreef 9
Amsterdam-Zuidoost 1105AZ
NL
Listed location countries
Age
Inclusion criteria
Age 18 * 50 years
Frequent physical activity: at least 10 km of running a week
Exclusion criteria
History of peptic ulcer disease
Known Barrett*s oesophagus
History of GI cancer
GI tract surgery (except appendectomy)
Use of drugs that affect GI function
Other organic gastro-intestinal diseases or functional disorders such as irritable bowel syndrome or functional dyspepsia
Pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL51220.018.14 |