In the current project we will investigate multiple risk factors and their interaction in a single study design, aiming to identify different profiles associated with social withdrawal behaviour in an Ultrahigh Risk and First Episode Psychosis…
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cohort clusters associated with social withdrawal behavior, based on disease
characteristics, cognitive and biological measures.
Secondary outcome
Persistency of, and fluctuations in withdrawal behavior as assessed with the
Experiences Sampling method.
Background summary
Although social withdrawal is relatively common in the general population, in
young people prone to develop schizophrenia its negative consequences are
far-reaching. No study thus far has disentangled the various mechanisms driving
social withdrawal in this vulnerable group of adolescents and young adults.
Given the large heterogeneity in clinical profiles it is likely that risk
factors for withdrawal differ greatly between subjects, requiring tailored
treatment strategies.
Study objective
In the current project we will investigate multiple risk factors and their
interaction in a single study design, aiming to identify different profiles
associated with social withdrawal behaviour in an Ultrahigh Risk and First
Episode Psychosis sample. By asking about social behavior after six months, we
will subsequently explore the stability of withdrawal over time and evaluate
whether the profiles derived from initial assessment are predictive for
withdrawal at 6 months follow-up.
Hypotheses:
We expect to find at least two distinct subgroups:
1. one in which social withdrawal is primarily related to deficits, such as
social cognitive-, and neurocognitive deficits, accompanied by disturbances
mental coherence and/or lower levels of Oxytocin, and:
2. one in which social withdrawal is primarily a reaction to clinical symptoms
(e.g. anxiety, paranoia, and/or depression).
In addition, we expect demoralization/-decreased self-esteem to moderate both
pathways
Study design
Six-month follow-up study with a naturalistic design.
Additionally, we will approach the first 20 participants of the study with the
question whether they (in addition to the original protocol , see Appendix page
16 of the custom protocol ) are willing to attend a 1 hour group session,
accompanied by professionals (researchers, health care ) , to brainstorm about
their own reasons for social withdrawal .
Study burden and risks
All participants will be assessed using a number of clinical scales/interviews,
a computergame (virtual reality), a smartphone application (ESM) that beeps for
six days at 10 random times throughout the day and neuropsychological tests. In
addition, 4 blood tubes will be drawn for Oxytocin purposes. The first 20
participants will also participate in a 1 hour -long brainstorming session. No
risks are attached to this study.
Meibergdreef 5
Amsterdam 1105AZ
NL
Meibergdreef 5
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
1. Aged 18 to 35.
2. Adequate command of the Dutch language to complete the assessment.;3. Meeting the criteria for:
- An At Risk Mental State for psychosis as defined by the Personal Assessment and Crisis Evaluation Clinic (PACE) (Yung et al 1998; Yung et al 2003) (for details see page 12 protocol), OR,
- A first-episode psychosis <3 year prior to first interview.
4. Having social withdrawal symptoms (at least moderate severity (3) on item 5.1 (social
isolation) of the CAARMS for the ARMS group or (3) on item N4 of the PANSS for the recent-episode group.
5. Able and willing to give informed consent.
Exclusion criteria
- IQ< 70
- Symptoms relevant for inclusion are explained by a medical disorder or
drugs or alcohol dependency
- Florid psychotic symptoms interfering with feasibility of conducting baseline
assessment
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL51493.018.14 |