We aim to identify neurobiological correlates of treatment response in children with DD and will examine how phonological and speech abilities are related to brain measures in children with DD as well as in controls. As a secondary objective, we…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Leerstoornis
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
In the proposed study, brain activation patterns and structural measures of the
connectivity of the brain are the dependent variables. We are particularly
interested in the neural correlates of treatment response and whether and how
this resembles or differs from age- and reading matched controls.
Secondary outcome
On a behavioural level, we will measure reading accuracy and fluency,
phonological awareness capacity, and response to online altered auditory
feedback (as a measure of speech perception/production interactions).
Background summary
Developmental Dyslexia (DD) is a brain-based difficulty in acquiring fluent
word decoding skills, and despite much effort to detect and treat DD as early
as possible, 20-40% of the children diagnosed with DD continue to lack decent
reading abilities after treatment. The behavioural and neural origins of the
response to treatment are underinvestigated and poorly understood. This study
employs an integrated brain-behaviour design to examine whether and how
responsiveness to treatment depends on the structural and functional brain
organization.
Study objective
We aim to identify neurobiological correlates of treatment response in children
with DD and will examine how phonological and speech abilities are related to
brain measures in children with DD as well as in controls. As a secondary
objective, we want to investigate how these relations differ for different
orthographies.
Study design
Structural and functional brain scans will be obtained from children with DD
with varying levels of responsiveness to treatment, and age- and reading
matched controls. Behavioural measures of reading, phonological and speech
abilities will be administered to use as covariates/regressors in the analyses.
Total time of participation from entrance till departure approximates 2 hours.
Study burden and risks
As reading is eminently an ability acquired in childhood, this study involves
children. There are no risks associated with participation in this study.
Several precautions are made to minimize any potential discomfort.
Montessorilaan 3
Nijmegen 6525 HR
NL
Montessorilaan 3
Nijmegen 6525 HR
NL
Listed location countries
Age
Inclusion criteria
Dyslexic children
- 11-13 years of age
- Children with dyslexia must have completed a DD treatment program according to the Dutch nationally standardized protocol (see Blomert, 2006)
- Speak Dutch as their first language
Control group
- 11-13 years of age or
- 8-10 years of age
- No diagnosis of dyslexia
- Speak Dutch as their first language
Exclusion criteria
- The participant has developmental dyslexia, but has not (yet) finished a DD treatment program.
- Significant hearing or visual impairments not correctable by glasses or hearing aids
- Any MRI counter-indications (e.g., metal implants, braces)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL55093.091.15 |