To make MRI suitable for an MRI-only workflow for magnetic resonance (MR)-guided (MR-linac) stereotactic radiotherapy for localized RCC. The objective of the current study will be MRI-sequence optimisation. Sequences will be optimized for MR-based…
ID
Source
Brief title
Condition
- Renal and urinary tract neoplasms malignant and unspecified
- Renal disorders (excl nephropathies)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To make MRI suitable for MR-guided (MR-linac) stereotactic radiotherapy for
localized RCC. The current predicate MRI work includes MRI-sequence
optimisation (to allow for MR-based delineation) and MR-guidance during
treatment.
Secondary outcome
Not applicable.
Background summary
The incidence of renal cell carcinoma (RCC) is increasing due to the increased
use of diagnostic imaging. 60-70% of the RCC are incidentaloma*s, often
classified as small renal masses (SRM). The standard treatment of RCC is
(partial-) nephrectomy. Alternatives to this treatment are less invasive
techniques like radio frequent ablation (RFA) and cryoablation (CA). So far,
only (less-) invasive treatment of RCC has been shown to be curative. An option
for a non-invasive curative treatment would be magnetic resonance imaging
(MRI)-guided radiotherapy. In this study we want to evaluate technical
feasibility of imaging lesions suspect for RCC by MRI. The purpose is to
develop and optimize an MRI scanning protocol for radiotherapy, in order to
work towards MRI-guided radiotherapy.
Study objective
To make MRI suitable for an MRI-only workflow for magnetic resonance
(MR)-guided (MR-linac) stereotactic radiotherapy for localized RCC. The
objective of the current study will be MRI-sequence optimisation. Sequences
will be optimized for MR-based delineation and MR-guidance during radiotherapy
treatment.
Study design
Prospective imaging (MRI) study.
Study burden and risks
Patients will undergo a contrast enhanced MRI scan with gadolinium, which will
take less than 45 minutes. The total visit to the department (including patient
preparation and changing of clothes) will last approximately 60 minutes. There
are no patient specific benefits by participating in this study, however this
study is a required step in the development of MRI-guided ablative radiotherapy
for operable and inoperable RCC patients in the future.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
- Patients with a solid lesion suspect for RCC or a cystic lesion Bosniak classification > IIF;
- * 18 years;
- Written informed consent.
Exclusion criteria
- Fulfilling one of the exclusion criteria for MRI at 1.5T/3T according to the protocol of the department of Radiology, UMC Utrecht;
- Fulfilling the exclusion criteria for the Gadovist gadolinium (glomerular filtration rate (GFR) of < 30 mL/min/1.73m2) (see also 'MRI contra indicaties Gadolinium gebruik' - guidelines UMC Utrecht, versie 5; april 2015);
- Patients with a known Gadovist allergy;
- Metastatic (regional or distant) RCC;
- Bosniak classification * IIF.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53592.041.15 |