The main objective of the study is to see if the test compounds can prevent the development of a psoriatic lesion induced in non-lesional skin from psoriasis patients which has been transplanted onto immune-deficient mice.
ID
Source
Brief title
Condition
- Autoimmune disorders
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Transplant epidermal thickness.
Secondary outcome
Number of dividing epidermal keratinocytes.
Background summary
Psoriasis is an auto-immune skin disease in which pro-inflammatory protein
mediators, released by skin cells and infiltrating cells, cause an abnormal
cell division and differentiation. It may be possible to treat psoriasis using
drugs aimed at preventing the synthesis of such mediators. The mouse transplant
model of psoriasis is a suitable one in which to test new compounds.
Study objective
The main objective of the study is to see if the test compounds can prevent the
development of a psoriatic lesion induced in non-lesional skin from psoriasis
patients which has been transplanted onto immune-deficient mice.
Study design
Small (6 mm diameter) biopsies will be removed from non-lesional skin of
volunteers with psoriasis and transplanted onto immune-deficient mice. A
psoriasis lesion will be induced in the transplant by injecting it
intra-dermally with the patient*s white blood cells. A week later we will begin
treating mice with the test and control chemicals. After 3 week the transplants
will be harvested.
Study burden and risks
The health risks associated with this research are small, possibly slight scar
formation or discoloration of skin at the biopsy sites.
Route des Colles, 2400
Sophia Antipolis 06920
FR
Route des Colles, 2400
Sophia Antipolis 06920
FR
Listed location countries
Age
Inclusion criteria
Patients with psoriasis vulgaris, mild to moderate.
Exclusion criteria
Volunteers should not:
- use light therapy or systemic drugs such as methotrexate or cyclosporine A.
- use local topical corticosteroids.
- develop psoriasis at wound sites (Köbner phenomenon).
- have other skin diseases.
- be pregnant
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54880.098.15 |