To explore the long-term prevalence of PICS in a representative sample of Dutch adult survivors intensive care treatment
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Combinatie van cogitieve, psychische en fysieke facoren. Tezamen met effecten op sociale factor en werk-inkomen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
To explore the long-term prevalence of PICS in a representative sample of Dutch
adult survivors after intensive care treatment
Questionaire consists of:
- Health related quality of life using the Short Form 36 Version 2 (SF-36)
questionnaire
- Health related quality of life using the EQ5-D questionnaire
- Physical impairments/rehabilitation using the SF-36 questionnaire
- Prevalence of post-traumatic stress using the Impact of Event Scale (IES)
questionnaire
- A novel question set designed to determine changes in family circumstances,
socio-economic stability and care requirements.
- Novel questions regarding the prevalence of a intervention.
For the complete questionnaire, see the attachment.
Secondary outcome
Treatment related information
- Age
- Sex
- BMI
- Race
- ICU stay (days)
- APACHE II / APACHE IV / SOFA score.
- scoring of delirium
- days of mechanical ventilation (endotracheal vs tracheotomy)
- noninvasive ventilation
- use of vasopressors
- use of (analgo)-sedatives (remifentanil/ propofol etc)
- use of analgetics (morfine / paracetamol / sufentanyl / fentanyl)
- use of Haldol / Is delirium present during ICU stay
- RASS score (if applicable)
Background summary
Recently a single term to identify the presence of one or more of these
impairments was acknowledged, it is called the *post-ICU syndrome* (PICS). To
date however most studies focused on a single specific impairment instead of
focusing on the complete sequalae of PICS. This has led to a widespread, but
diffuse knowledge of different ICU related complications.
Because until recently there was no uniform term, observational and
intervention studies focused on specific subsets of PICS. Interventions to
improve different impairments may be addressed by the following interventions:
ICU diaries, early in-ICU psychological intervention, and post-ICU coping
skills training, and intensive care follow-up clinics. To our knowledge
evidence-based guidelines are lacking. Despite this recent studies that
demonstrated several tools that might intervene in the developement of PICS, a
recent study in the UK showed that survivors of critical illness face a
negative impact on employment and commonly have a care requirement after
discharge from hospital. This last study pointed out that a broader perspective
on PICS is essential before studying possible intervention methods (for example
intensive care follow-up clinics).
We therefore believe that more research of appropriate methodological quality
using PICS as a syndrome is needed. Subsequently a multi-disciplinary and
multilevel-based approach is paramount to a successful prevention and
intervention practice.
Study objective
To explore the long-term prevalence of PICS in a representative sample of Dutch
adult survivors intensive care treatment
Study design
Multi-centre retrospective questionnaire-based study in survivors after ICU
admission, respectively 1, 6 , 12, and 24 months after ICU discharge.
Study burden and risks
There are no risks associated with this retrospective questionnaire-based
approach. Using this method, no additional risk or burden is involved, waiver
of consent is used and no prior written informed consent is required.
Kleiweg 500
Rotterdam 3045PM
NL
Kleiweg 500
Rotterdam 3045PM
NL
Listed location countries
Age
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- Patients between 18-65 years of age. Patients > 65 were not included because of 2 reasons: The survey has a low response rate in the >65 population, and because we wanted to determine the impact on employment and economic impact.
- Patients admitted for the first time to the ICU during their hospital stay with an ICU length of stay >= 48 h and fulfilling the following criteria:
- Severe sepsis and septic shock was defined according to previously published criteria6.
- Patients who received a tracheotomy during their ICU stay
- Patients who were diagnosed with ARDS during their hospital stay
- Patients with prolonged mechanical ventilation (> 7 days)
Exclusion criteria
- Patients younger than 18 years
- who were pregnant
- known participation in another randomized controlled biomedical study
- elective postoperative admission, uncomplicated during ICU admission
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL56169.101.15 |