Is it possible to increase the spatial match between PET and CT imaging with the use of a respiratory instructed breath hold CT?
ID
Source
Brief title
Condition
- Respiratory and mediastinal neoplasms malignant and unspecified
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The mismatch between PET and CT measured for standard low-dose CT and PET, and
breath-hold low-dose CT and PET for 1 anatomical location (lung-liver
transition)
Secondary outcome
The mismatch between PET and CT measured for standard low-dose CT and PET and,
breath hold low-dose CT and PET for lung lesions, measured by:
• Mismatch between centroids of the lesions on PET and CT
• Mismatch between lesions on PET and CT measured with the Jaccard similarity
coefficient
• Effect of attenuation correction of the CT on the PET reconstruction measured
by the mean tracer uptake.
Background summary
Respiratory motion artefacts during positron emission tomography (PET) may
introduce a significant effect on quantification of radiotracer uptake in PET
images. Additional miscalculation of uptake can be caused by inappropriate
attenuation correction due to a spatial mismatch between PET and CT. Both
reducing respiratory motion artefacts and matching PET and CT are important for
an accurate quantification in radiotherapy planning and therapy response
monitoring of lung cancer.
Recently the department of Radiology and Nuclear Medicine (Radboudumc) acquired
a tool to reduce respiratory motion artefacts in PET images. In the recent year
different studies were performed to find the best method to improve the match
between PET and CT to optimize PET/CT imaging for patients with lung cancer,
however these methods did not provide the optimal results.
Study objective
Is it possible to increase the spatial match between PET and CT imaging with
the use of a respiratory instructed breath hold CT?
Study design
technical efficacy feasibility study
Intervention
Twenty patients, will undergo a respiratory gated PET/CT protocol, consisting
of a topogram, a low-dose CT and a respiratory gated PET scan. In addition a
low-dose CT will be made with a respiratory instruction.
Before these 20 patients are scanned, 5 patients will be scanned with the
standard protocol. For these patients only the breathing instructions are given
and recorded, the additional CT scan is not performed.
Study burden and risks
The patient will receive a respiratory gated PET/CT scan. This scan will be
used for routine clinical care. Furthermore, an additional low-dose CT will be
acquired. The additional radiation dose corresponds to approximately 37% of the
total dose. This additional scan will not be harmful to the patient and is
classified as low-risk (NFU risk classification).
Geert Grooteplein-Zuid 10
Nijmegen 6525 GA
NL
Geert Grooteplein-Zuid 10
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
Patients with suspected lung malignancy, who will have a PET/CT scan.
Exclusion criteria
Mentally incompetent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL52837.091.15 |