In this study, behavioral tests will be performed during the fMRI scan to investigate the brain*s response to these tests. Behavioral tests will also be performed outside the scanner. The results of the study will be used for optimizing the fMRI…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
niet van toepassing
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
fMRI optimalisation
Secondary outcome
n/a
Background summary
One of the techniques used in this study, functional magnetic resonance imaging
(fMRI), uses strong magnetic fields to measure brain activity based on changes
in blood flow in the brain. This technique relies on the fact that cerebral
blood flow and neuronal activation are coupled. When an area of the brain is in
use, blood flow to that region increases.
Study objective
In this study, behavioral tests will be performed during the fMRI scan to
investigate the brain*s response to these tests. Behavioral tests will also be
performed outside the scanner.
The results of the study will be used for optimizing the fMRI technique and the
application of behavioral tests for use in future studies on drugs that may
have an effect on brain activity.
Study design
The study will be performed in 2 parts, Parts A and B. Part A will be performed
in 5 volunteers who will participate in 1 visit with fMRI tasks and behavioral
tasks based on which the fMRI settings may be optimized and behavioral
assessments may be adapted for use in Part B. Part B will be performed in 30
volunteers who will participate in 2 visits during which fMRI tasks and
behavioral tasks will be performed. It will determine whether the results of
the first visit are reproducible in the second visit.
Study burden and risks
With regard to the fMRI, no radioactivity will be applied and there are no
adverse effects to be expected.
6 Falcon Way, Shire Park
Welwyn Garden City AL7 1TW
GB
6 Falcon Way, Shire Park
Welwyn Garden City AL7 1TW
GB
Listed location countries
Age
Inclusion criteria
* willing to participate in this study
* healthy male or female
* age between 18 and 45 years of age, inclusive
* BMI between 18 and 30 kilograms/meter2, inclusive, body weight between 50 and 100 kilogram, inclusive
* non-smokers and smokers (smoke less than 11 cigarettes per day (or comparable amount of cigars or pipe)
Exclusion criteria
Suffering from hepatitis B, hepatitis C, cancer or HIV/AIDS.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54292.056.15 |