The main objective is to investigate whether ionized magnesium concentration varies during one day, and whether it is changed after one bout of exercise.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
micronutrienten
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is ionized magnesium concentration in serum.
Secondary outcome
Total magnesium concentration in serum
The machine also analysis the next parameters in the same sample:
Ca2+, pH, pO2, pCO2, hematocrit, Na, K, glucose and lactate.
These parameters are also measured and used as outcome measures.
There is no extra blood needed and also no extra analysis.
Background summary
Magnesium is an essential micronutrient for health and exercise performance.
Deficiencies are common, especially in case of insufficient diets. Athletes are
a population at risk of magnesium deficiency, as they can have strong
nutritional (dis)believes and increased losses through sweat. That is why
monitoring magnesium status in athletes is very important. Ionized magnesium is
the active form of total magnesium, this value might be even more important
than total magnesium. However, whether ionized magnesium is influenced by day
variation is not clear yet. In addition: one bout of exercise can change
magnesium status and probably ionized magnesium status. For people active in
sports it is important to be aware of this variation in magnesium status, to
prevent the diagnosis of false inadequate magnesium status. Therefor it is the
aim of this proposal to determine whether ionized magnesium varies within one
day and whether it changes after an acute bout of exercise.
Study objective
The main objective is to investigate whether ionized magnesium concentration
varies during one day, and whether it is changed after one bout of exercise.
Study design
This will be a cross-over design. With screening and preliminary tests before
the exercise test day and the non-exercise test day. The order in which
exercise day and non-exercise day will be done, will be randomly divided
between the participants.
Intervention
A rest day and an exercise day
At exercise day: an exercise test of 90 min at 70% of VO2max.
Bloedsamples are taken at set time points during rest day and exercise day
Study burden and risks
Exercise tests may cause muscle pain. This is innocent and will only be for a
couple of days.
Blood samples can be uncomfortable. Bruises may appear, but will be gone in a
few days.
Bomenweg 2 building 307
Wageningen 6307 HD
NL
Bomenweg 2 building 307
Wageningen 6307 HD
NL
Listed location countries
Age
Inclusion criteria
Age: 18 - 45 y
BMI: 18.5 - 25
Minimal of 5 hours of training per week, for at least 2 years
Used to bike, at least 5 hours per week in high season
No Mg and / or Ca supplementation during study
No blood donation, during or in the 6 weeks preliminary the study
Suitable veins
No chronic medication, with the exception of paracetamol and or birth control
No antibiotics in the month preliminary the study
Good health
Mg intake >420 mg for men and >320 mg for women (estimated with FFQ)
Serum Mg > 0.7 mmol/L
Willing to give blood
Able to be present and participate at all test days
Exclusion criteria
Chronical illness
Use of medication with the exception of paracetamol and or birth control
Mg and or Ca supplementation use
Inadequate Mg intake (according to FFQ)
Working at Human Nutrition - Wageningen University
Msc thesis or internship at Human Nutrition - Wageningen University
Participating in other scientific research (with the exception of EetMeetWeet)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL54333.081.15 |