Key Question: What is the level of cognitive performance in healthy siblings of juvenile myoclonic epilepsy patients compared to that of patients with juvenile myoclonic epilepsy?
ID
Source
Brief title
Condition
- Seizures (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
raw scores on the neuropsychological tests.
Secondary outcome
geen
Background summary
There is much insight in cognition in patients with a symptomatic epilepsy, but
there is little insight in cognition in patients with idiopathic generalized
epilepsy (IGE).
Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized
epilepsy. There is evidence in the literature that JME patients have more
cognitive deficits in comparison with healthy individuals. Genetics may play a
role in the development of JME, which may imply that the cognitive functioning
of relatives of JME patients are also affected. However ther is little
research. The purpose of this study is to gain more insight into the cognition
of patients with JME and cognition in healthy siblings of patients with JME.
Study objective
Key Question: What is the level of cognitive performance in healthy siblings
of juvenile myoclonic epilepsy patients compared to that of patients with
juvenile myoclonic epilepsy?
Study design
A total of three groups will be measured.
- 30 JME patients
- 30 healthy siblings of patients with epilepsy
In each subject a brief neuropsychological assessment is conducted with the
following tests:
1. Trail making test
2. Word fluency test / woordopnoemen
3. Stroop Test
4. Digit span / Digit
5. I7 Impulsivity test
Study burden and risks
The neuropsychological tests will take about half an hour.
Achterweg 5
Heemstede 2103 SW
NL
Achterweg 5
Heemstede 2103 SW
NL
Listed location countries
Age
Inclusion criteria
In generally good health
Normal cognitive functioning (IQ>80)
Speaking and reading Dutch
Diagnosis of JME confirmed
Older than 12 years
Exclusion criteria
Any major neurological condition other than JME
Any psychiatric condition (Axis I, Axis II)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL53705.058.15 |